Rational design of high functional biosupra and development of therapeutic evaluation system with disease models
Rational design of high functional biosupra and development of therapeutic evaluation system with disease models
批准号:
17H04102
负责人:
ITOH Kohji
金额:
$11.4万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2017
资助国家:
日本
项目状态:
已结题
起止时间:
2017-04-01 至 2020-03-31
中文摘要
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英文摘要
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In vivo gene therapy for GM2 gangliosidoses with novel AAV9/3-CMV-modHEXB vector.
使用新型 AAV9/3-CMV-modHEXB 载体对 GM2 神经节苷脂病进行体内基因治疗。
DOI:
--
发表时间:
2020
期刊:
影响因子:
--
作者:
[Kohji Itoh, Yukiya Ohnishi, Daisuke Tsuji, Ryo-suke Watanabe, Nijiho Kamori, Katsuhito Asai, and Shin-ichi Muramatsu]
通讯作者:
and Shin-ichi Muramatsu
GM2ガングリオシドーシスにおける神経細胞死誘導メカニズムの解析
GM2神经节苷脂沉积症诱导神经元死亡的机制分析
DOI:
--
发表时间:
2020
期刊:
影响因子:
--
作者:
[中江 隆豊, 辻 大輔, 大西 恭弥, 眞継 毅, 伊藤 孝司]
通讯作者:
伊藤 孝司
GM2ガングリオシドーシスに対する,改変型β-Hexosaminidase B発現AAVベクターによる遺伝子治療法開発
使用表达修饰的 β-己糖胺酶 B 的 AAV 载体开发针对 GM2 神经节苷脂沉积症的基因治疗方法
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[大西 恭弥, 辻 大輔, 加守 虹穂, 村松 慎一, 伊藤 孝司]
通讯作者:
伊藤 孝司
AAVベクターによるGM2ガングリオシドーシスに対する遺伝子治療
使用 AAV 载体进行 GM2 神经节苷脂沉积症的基因治疗
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[大西 恭弥, 辻 大輔, 村松 慎一, 伊藤 孝司]
通讯作者:
伊藤 孝司
Study on in cellulo crystallization of human neuraminidase 1 and association with cathepsin A.
人神经氨酸酶1的纤维结晶及其与组织蛋白酶A的关联研究。
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Jun Tsukimoto, Toshiki Iniwa , Yuto Horii, Soichiro Nishioka, Kohji Itoh]
通讯作者:
Kohji Itoh
共 86 条
Development of neoglycobiologics and application for drug discovery for lysosomal diseases
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批准号:26293120
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.57万
-
财政年份:2014
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负责人:ITOH Kohji
-
依托单位:
Establishment of induced neurons (iN cells) derived from lysosomal disease patients involving neurological symptoms and elucidation of regulatory mechanism of neurodegeneration
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批准号:26670269
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2014
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负责人:ITOH Kohji
-
依托单位:
Practicing Engineering Classes Incorporating Computer-Assisted Collaborative Learning
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批准号:24501164
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2012
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负责人:ITOH Kohji
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依托单位:
Discovery of novel compounds regulating traffic to lysosomes and application for development of therapeutics
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批准号:24659262
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:ITOH Kohji
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依托单位:
Development of neo-biologics targeted on protein-protein interaction sites
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批准号:23390140
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.9万
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财政年份:2011
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负责人:ITOH Kohji
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依托单位:
Learning Assistant System Providing Materials with Knowledge Relational Maps to Help Retrieval and a Work Place for Solving Problems in Collaboration to Promote Generalized Knowledge Usability
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批准号:21500920
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2009
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负责人:ITOH Kohji
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依托单位:
Computer-Assisted Second Language Learning by Going Back and Fourth in a Collection of Layered Learning Materials for Formative Learning
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批准号:15300285
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.94万
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财政年份:2003
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负责人:ITOH Kohji
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依托单位:
A Study on Network Media Systems Assisting Life-Long learning in Collaboration
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批准号:12558014
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.62万
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财政年份:2000
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负责人:ITOH Kohji
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依托单位:
Development and application of tissue-directed medicinal resources based on biotechnology
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批准号:12470503
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.09万
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财政年份:2000
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负责人:ITOH Kohji
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依托单位:
A Study on Collaborative Learning Environment Assisting Learning by Teaching Problem-Solving Strategies to a Computer Agent
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批准号:09558019
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.02万
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财政年份:1997
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负责人:ITOH Kohji
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依托单位:
Computer-Assisted Learning of Japanese as Second Language Based on a Dialog Text Database with Situated and Functional Indices as well as on a Diagnostic Parser
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批准号:09680303
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1997
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负责人:ITOH Kohji
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依托单位:
Deficiency of Endothelin-Degrading Enzyme and Abnormality in Central Nervous System
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批准号:09670168
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.22万
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财政年份:1997
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负责人:ITOH Kohji
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依托单位:
Computer-Assisted Leaning Based on Negotiation for Accordance Mediated by Multi-Dimensional Media Communication
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批准号:07458034
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.22万
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财政年份:1995
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负责人:ITOH Kohji
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依托单位:
A System for Assisting Negotiation in Group Learning using Network
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批准号:07558022
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$6.46万
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财政年份:1995
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负责人:ITOH Kohji
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依托单位:
Research on Display Methods and Poiniting Mechanisms for Effective 3D manipulation in CAI System
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批准号:05558016
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$6.72万
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财政年份:1993
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负责人:ITOH Kohji
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依托单位:
A Problem-Solving Learners' Work bench System as an Interactive External Intelligence
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批准号:05452348
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1993
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负责人:ITOH Kohji
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依托单位:
A General Purpose Hyper-Media System with Knowledge-Based Retrieval and Guidance
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批准号:02452302
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.88万
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财政年份:1990
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负责人:ITOH Kohji
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依托单位:
An Extensive Study on Knowledge-Based Systems in Education
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批准号:63302071
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$2.88万
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财政年份:1988
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负责人:ITOH Kohji
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依托单位: