Control and evolution of somite pattern formation during early development (C06)

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Vertebrate somitogenesis is being studied in a diverse set of animals, and ist understanding has reached a level where theoretical modeling can provide important insights. Here, we focus on an evolutionary transition in the oscillatory Expression pattern of the genes involved in the 'somitogenesis clock*. Such a transition appears to have occurred between Zebrafish and Medaka. We will use theoretical modeling to study the phenotypic variability of the regulatory network controlling somitogenesis, and will perform experiments to characterize the effects of the regulatory evolution in key clock elements.