The cognitive control of long-term memory: Neural dynamics in space and time

一般认为，长期记忆是由控制过程介导的，控制过程引导记忆检索，以便有选择地恢复与当前任务和目标相关的信息。控制记忆检索是由内侧颞叶（MTL）、前额叶皮层（PFC）和其他皮层区域之间的动态相互作用产生的。近年来的功能成像、ERP和神经心理学研究已经开始揭示受控记忆提取的子过程及其神经关联。然而，关于上述大脑系统完成受控记忆检索的动态相互作用的重要问题仍未解决。利用事件相关电位（ERP）和脑电图的联合变量以及区域间相位同步的测量，本研究旨在研究检索方向，即由检索线索启动的特定处理形式及其神经相关性。详细地，我们想研究有助于检索方向的启动和维持的因素，以及这些控制过程对记忆检索的其他组成部分的影响。

It is generally assumed that long-term memory is mediated by control processes that guide memory retrieval in order to selectively recover information relevant for current tasks and goals. Controlled memory retrieval results from a dynamic interplay between the medial temporal lobe (MTL), the prefrontal cortex (PFC), and other cortical areas. Recent functional imaging, ERP and neuropsychological studies have started to disclose the subprocesses of controlled memory retrieval and their neural correlates. However, important issues concerning the dynamic interplay of the aforementioned brain systems accomplishing controlled memory retrieval are still unresolved. Using combined event-related potential (ERP) and EEG variables in addition to measures of interareal phase synchrony, the present proposal aims at examining retrieval orientations, i.e. the specific form of processing initiated by a retrieval cue, and their neural correlates. In detail we want to investigate factors contributing to the initiation and maintenance of retrieval orientations and the influence of these control processes on other components of memory retrieval.