Functional antigen matching in corneal transplantation (FANCY)

角膜移植中的功能性抗原匹配（FANCY）

• 批准号: 73670179
• 负责人: Professor Dr. Daniel Böhringer
• 金额: --
• 依托单位: Klinik für Augenheilkunde
• 依托单位国家: 德国
• 项目类别: Clinical Trials
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/73670179?language=en
• 关键词: Functional; antigen; matching; corneal; transplantation

This is our continuation application for DFG. We already announced this application for continuation in our original proposal. The summary from our original proposal still holds: Corneal diseases are among the five most common causes of blindness. Keratoplasty can potentially restore vision in most cases. Immunological graft reactions, however, may induce irreversible graft failure in 20-50%. Matching for transplantation antigens is potentially effective for a lifetime without side-effects contrary to the pharmacological approaches. The purpose of the FANCY trial is to demonstrate superiority of HLA matching in comparison to standard care, namely sequential (‘random’) graft assignment.So far, we succeeded in screening the 720 patients we strived for. We owe this success to our highly motivated investigators. These compensated the drop out of two big centres from the start. We additionally managed to overcome the unforeseeable black-out of our monitoring contractor in the midst of the patient recruiting period. We therefore need three additional years to complete the HLA matching and follow up. However, the FANCY trial is still on budget despite the delays. We herein apply for the originally announced funding beyond the first three years. Without this funding, all endeavours so far would be of no avail.

这是DFG的延续申请。我们在原来的建议中已经宣布了这一延续申请。我们最初提案的总结仍然成立：角膜疾病是五种最常见的致盲原因之一。角膜移植术在大多数情况下可以恢复视力。然而，免疫移植物反应可能导致20- 50%的不可逆移植物衰竭。与药理学方法相反，移植抗原的匹配可能终生有效，没有副作用。FANCY试验的目的是证明HLA配型与标准治疗相比的优越性，即序贯（“随机”）移植分配。到目前为止，我们成功地筛选了720名我们努力争取的患者。我们将这一成功归功于我们积极进取的调查人员。这弥补了从一开始就退出两个大中心的损失。我们还设法克服了在患者招募期间无法预见的监测承包商停电。因此，我们需要额外三年的时间来完成HLA配型和随访。然而，尽管有拖延，FANCY试验仍在预算范围内。我们在此申请最初宣布的三年后的资助。没有这笔资金，迄今为止的所有努力都将是徒劳的。