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Release of mercury from dental amalgam fillings and behavior of the mercury in a living body

牙科汞合金填充物中汞的释放以及汞在活体内的行为

基本信息

批准号：
09672024
负责人：
TAKAHASHI Yoshifumi
金额：
$ 2.24万
依托单位：
Aichi-Gakuin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672024/
关键词：
Amalgam Rat Mercury Organ Blood Photo emulsion method Mercury granule 総水銀有機水銀胎児血液

项目摘要

1. Release of Mercury from Dental Amalgam Fillings in pregnant Rats and Distribution of Mercury in Maternal and Fetal Tissues.Experimental animals received one amalgam filling. On days 2, 8 and 15 of pregnancy, Hg exhaled by the rat was measured serially for 24 hours. The animals showed large amounts of Hg on day 2. The amount of Hg tended to decline as time elapsed but marked amounts were observed even on day 15. The amount of Hg increased particularly after the animal took food. In mothers, the highest Hg concentration was found in the kidneys followed, in decreasing order, by the lungs, liver, placenta and brain. The highest Hg concentration among fetal organs was found in the liver, followed by the kidneys and brain. Hg concentrations in maternal organs and fetal liver were significantly higher than those of the controls, and concentrations in maternal whole blood, erythrocyte and plasma, and fetal whole blood were also significantly higher. Hg concentrations in the fetal brain, li … More ver, kidneys and whole blood were lower than those of the maternal tissues.2. Release of Mercury from Dental Amalgam Fillings in Pregnant Rats and Mercury Contents in Their Blood and Urine SamplesTwenty rats were equally divided into four groups (Groups A, B, C and D). Groups B, C and D received amalgam fillings in 1, 2 and 4 maxillary molars, respectively. Group A received no treatment. On days 2, 8 and 15 of pregnancy, Hg exhaled by the rat was measured serially for 24 hours. Urine samples were collected at intervals of 2 days. The amount of Hg tended to decline as time elapsed but marked amounts were observed even on day 15. Blood samples were drawn directly from the heart. The amalgam area was calculated using a personal computer. Hg concentrations in maternal whole blood, plasma and urine correlated to the amalgam area and Hg vapor exhaled by the rats.3. Histological Observation of Mercury in rat tissues with amalgam fillings.Twenty female rats were used as experimental animals and ten rats were employed as controls. Experimental animals received 4 amalgamfillings. In sections from the brain and liver of the experimental animals, Hg deposits were not found, while the largest deposits of Hg were found in the kidneys. Dense accumulations of Hg were located primarily in the proximal tubule cells. Less

1.银汞合金充填体中汞在孕鼠体内的释放及汞在母体和胎儿组织中的分布在妊娠第2、8和15天，连续24小时测量大鼠呼出的汞。动物在第2天出现大量的汞，随着时间的推移，汞的含量呈下降趋势，但在第15天仍有明显的汞含量。汞的含量在动物进食后增加。在母亲中，汞浓度最高的是肾脏，其次是肺、肝脏、胎盘和脑。胎儿器官中汞浓度最高的是肝脏，其次是肾脏和脑。母血、红细胞、血浆和胎儿全血中汞浓度显著高于对照组。胎脑中汞的浓度，li…肝脏、肾脏和全血低于母体组织。孕鼠银汞合金充填体汞释放及血、尿汞含量20只大鼠平均分为A、B、C、D四组。B、C、D组分别对1、2、4颗上颌磨牙进行银汞合金充填。A组不接受任何治疗。在妊娠第2、8和15天，连续24小时测量大鼠呼出的汞。每隔2天采集一次尿样。汞的含量随着时间的推移呈下降趋势，但即使在第15天也观察到明显的含量。血液样本直接从心脏采集。使用个人计算机计算汞齐面积。母血、血浆和尿汞浓度与银汞合金面积和大鼠呼出汞蒸气呈正相关。银汞合金充填大鼠组织中汞的组织学观察20只雌性大鼠作为实验动物，10只大鼠作为对照。实验动物接受4颗银汞合金充填。在实验动物的大脑和肝脏切片中，没有发现汞沉积，而在肾脏发现了最大的汞沉积。汞的致密堆积主要位于近端小管细胞内。较少