Urban rat exposure and pediatric asthma

项目摘要/摘要 研究：哮喘是生活在城市中心的儿童最常见的慢性病，接触老鼠 过敏原会在致敏儿童中引发哮喘。这一奖项的目的是评估两国关系 使用新技术评估老鼠暴露与儿童哮喘严重程度之间的关系，包括 关于老鼠种群动态和公开可获得的与老鼠有关的311投诉电话的生态研究，围绕 家庭和学校环境。在市中心学校注册的内城儿童的既定队列 哮喘研究(SICAS)和青年睡眠环境评估(EASY)研究(皮万达博士 Phipatanakul)将用于研究老鼠暴露对儿童哮喘严重程度的影响。这项研究是独一无二的 而且新颖，因为这将是第一次评估老鼠种群动态与哮喘的关系 严肃性。结果可能会导致旨在减少共生啮齿动物数量的干预性试验 采取预防措施，减少接触其产生的过敏原。 职业发展：Marieke Rosenbaum博士是一名兽医和公共卫生科学家，他寻求 将临床研究和兽医结合起来设计干预措施，以减少 城市周边家养野生动物对人类健康的影响。在这个奖项的过程中，罗森鲍姆博士将获得 重要的人类临床研究技能，学习高级统计和建模，探索社区 参与度是她K08培训计划的三大支柱。拟议的研究和罗森鲍姆博士的 职业发展轨迹与NIEHS 2018-2023年战略主题1(高级环境健康)密切相关 科学)和2(促进数据到知识到行动)，开辟了一条跨学科的新路线 关于城市环境、老鼠暴露和儿童哮喘的调查。 环境：罗森鲍姆博士将接受菲帕塔纳库尔博士的指导，他是流行病学、临床试验、 哮喘和过敏性疾病的临床研究。她的顾问团队包括Jon Runstadler(DVM， 博士)、Jessica Leibler(博士、硕士)和Janis Breeze(公共卫生硕士)，他们与主要导师一起拥有 投入他们的时间、资源和专业知识来促进Rosenbaum博士的职业发展和成功 完成拟议的项目。在此授勋期间，罗森鲍姆博士将完成课程工作并 在塔夫茨大学、波士顿大学和哈佛大学接受培训，她将得到塔夫茨夫妇的支持 大学临床转化科学学院，为初级教师提供职业发展培训。这个 导师和机构及其附属机构创造的学术环境提供了一个最佳的环境 专门针对拟议的研究和培训进行学习和合作。

Project Summary/Abstract Research: Asthma is the most common chronic disease of children living in urban centers, and exposure to rat allergen can trigger asthma in children who are sensitized. The goal of this award is to evaluate the relationship between rat exposure and asthma severity in children using novel techniques to estimate rat exposure, including ecological studies of rat population dynamics and publicly available rat-related 311 complaint calls, around the home and school environment. Established cohorts of inner-city children enrolled in the School Inner-City Asthma Study (SICAS) and Environmental Assessment of Sleep in Youth (EASY) study (PI, Dr. Wanda Phipatanakul) will be used to study the impact of rat exposure on pediatric asthma severity. This study is unique and novel because it will be the first to evaluate the relationship between rat population dynamics on asthma severity. Results may lead to interventional trials designed to reduce commensal rodent abundance as a primary prevention measure to reduce exposure to the allergens they produce. Career Development: Dr. Marieke Rosenbaum is a veterinarian and public health scientist who seeks to integrate clinical research and veterinary medicine to design interventions that reduce the negative impact of urban peri-domestic wild animals on human health. Over the course of this award, Dr. Rosenbaum will gain important human clinical research skills, learn advanced statistics and modeling, and explore community engagement as the three pillars of her K08 training program. The proposed research and Dr. Rosenbaum’s career trajectory closely align with NIEHS 2018-2023 strategic themes 1 (Advance Environmental Health Science) and 2 (Promoting Translation – Data to Knowledge to Action) by opening a new line of transdisciplinary investigation about the urban environment, rat exposure, and pediatric asthma. Environment: Dr. Rosenbaum will be mentored by Dr. Phipatanakul, an expert in epidemiology, clinical trials, and clinical investigation in asthma and allergic diseases. Her team of advisors include Jon Runstadler (DVM, PhD), Jessica Leibler (DrPH, MS), and Janis Breeze (MPH), who together with the primary mentor have committed their time, resources, and expertise to facilitate Dr. Rosenbaum’s career development and successful completion of the proposed project. During this award period, Dr. Rosenbaum will complete course work and training at Tufts University, Boston University, and Harvard University, and she will be supported by the Tufts University Clinical Translational Science Institute, which offers career development training for junior faculty. The academic environment created by the mentor and institutions and their affiliates provides an optimal environment for learning and collaborating specific to the proposed research and training.