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Induction of apoptosis of taste bud cells by denervation and administration of drugs

Induction of apoptosis of taste bud cells by denervation and administration of drugs
通过去神经和给药诱导味蕾细胞凋亡
批准号:
09671861
负责人:
TAKEDA Masako
金额:
$1.92万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1999

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中文摘要
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英文摘要
Gustatory nerve sectioning causes degeneration and disappearance of taste bud cells and after regeneration of the nerves, the taste bud cells regenerate. We recently (1996) reported that glossophaiyngeal nerve sectioning induced apoptosis of taste bud cells in the mouse circumvallate papillae. Thus, the trophic substance released from gustatory nerves, that causes differentiation and maintains taste bud cells, may have an inhibitory effect on apoptosis of taste bud cells.In this study we tried to examine the nature of the trophic substance. An immunohistochemical reaction for Bcl-2 and Bcl-x, which inhibit apoptosis, revealed positive staining of the epithelial cells in all layers of the epithelium and taste bud cells. Potassium ionophore valinomycin triggers an increase of the cytoplasinic calcium concentration. Valinomycin was injected in the mucosa near the circumvallate papillae in adult dd-mice tongues. Paraffin sections were cut and treated by method of DNA nick end labeling which detects apoptotic nuclei in situ. 20 and 24 h after injection of valinomycin, positive nuclei were scattered in the taste buds. The result shows that a rise in the intracellular content of calcium ion induces apoptosis of taste bud cells. Also we have established the method to inject the substances into the circumvallate papillae. We are examining whether apoptosis of the taste bud cells after nerve sectioning would be interfered by treatment of various kinds of growth factors such as BDNF and GDNF.
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Yuko Suzuki: "Phagocytic cells in the taste buds of rat circumvallate papillae after denervation" Chemical Sences. 21. 476-476 (1996)
Yuko Suzuki:“去神经支配后大鼠味蕾中的吞噬细胞周围乳头”化学感觉。
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通讯作者:
武田正子: "神経切断後およびコルヒチン投与後の味蕾細胞のアポトーシス" 日本味と匂学会誌. 3・3. 556-559 (1996)
Masako Takeda:“神经切断和秋水仙碱给药后味蕾细胞的凋亡”日本味觉学会杂志 3・3(1996)。
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Y. Suzuki: "Effect of denervation on lymphocytes and dendritic cells in the rat circumvallate and foliate papillae"Anatomy and Embryology. 196. 447-455 (1997)
Y. Suzuki:“去神经支配对大鼠外周和叶状乳头中淋巴细胞和树突状细胞的影响”解剖学和胚胎学。
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Masako Takeda: "Expression of the neural cell adhesion molecule in mouse taste buds after denervation" Journal of Electron Microscopy. 48,1. 39-45 (1999)
Masako Takeda:“去神经支配后小鼠味蕾中神经细胞粘附分子的表达”电子显微镜杂志。
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