T 细胞在带状疱疹后神经痛发作中的作用。-猫眼课题宝

T 细胞在带状疱疹后神经痛发作中的作用。

批准号：

19603013

负责人：

TAKEDA Masako

金额：

$2.91万

依托单位：

International University of Health and Welfare

依托单位国家：

日本

项目类别：

Grant-in-Aid for Scientific Research (C)

财政年份：

2007

资助国家：

日本

项目状态：

已结题

起止时间：

2007 至 2009

来源：

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19603013/

关键词：

帯状疱疹後神経痛 HLA遺伝子帯状疱疹痛モデルマウス T細胞帯状庖疹後神経痛 MHC遺伝子帯状疱疹後痛モデルマウス CD4陽性T細胞欠損マウス

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英文摘要

Dorsal Root Ganglion (DRG) in the postherpetic neuralgia model mouse have shown the possibility that CD4 positive T cells are involved in the onset of postherpetic neuralgia. If CD4 positive T cells are involved in the onset of postherpetic neuralgia, CD4 knockout mouse will not develop to postherpetic neuralgia from herpes zoster. But in this study, there were no significant differences between control mouse and CD4 knockout mouse as to the onset of postherpetic neuralgia. Therefore it is suggested that MHC genes (H-2^b) itself are directly involved in the onset of postherpetic neuralgia.

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