Role of T cells in the onset of postherpetic neuralgia.

T 细胞在带状疱疹后神经痛发作中的作用。

• 批准号: 19603013
• 负责人: TAKEDA Masako
• 金额: $ 2.91万
• 依托单位: International University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19603013/
• 关键词: 帯状疱疹後神経痛; HLA遺伝子; 帯状疱疹痛モデルマウス; T細胞; 帯状庖疹後神経痛; MHC遺伝子; 帯状疱疹後痛モデルマウス; CD4陽性T細胞欠損マウス

Dorsal Root Ganglion (DRG) in the postherpetic neuralgia model mouse have shown the possibility that CD4 positive T cells are involved in the onset of postherpetic neuralgia. If CD4 positive T cells are involved in the onset of postherpetic neuralgia, CD4 knockout mouse will not develop to postherpetic neuralgia from herpes zoster. But in this study, there were no significant differences between control mouse and CD4 knockout mouse as to the onset of postherpetic neuralgia. Therefore it is suggested that MHC genes (H-2^b) itself are directly involved in the onset of postherpetic neuralgia.

在带状疱疹后神经痛模型小鼠背根神经节（DRG）中显示了CD 4阳性T细胞参与带状疱疹后神经痛发作的可能性。如果CD 4阳性T细胞参与带状疱疹后神经痛的发生，则CD 4基因敲除小鼠不会从带状疱疹发展为带状疱疹后神经痛。但在本研究中，对照小鼠和CD 4基因敲除小鼠之间在带状疱疹后神经痛的发生方面没有显著差异。因此，这表明MHC基因（H-2 ^b）本身直接参与带状疱疹后神经痛的发病。