权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Interaction of blood flow and nerve function in the dental pulpitis

牙髓炎中血流与神经功能的相互作用

基本信息

批准号：
09671944
负责人：
SASANO Takashi
金额：
$ 1.47万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671944/
关键词：
pulpal blood flow sensory nerve autonomic nerve pulpitis pulp vitality test.神経原性炎症逆伝導性血管拡張 basal blood flow

项目摘要

(1) The dental pulp is rich in both nerves and blood vessels. These nerves and vessels are closely related to each other. Particularly in the dental pulp, which is densely innervated by sensory nerve axons, antidromic vasodilatation mediated via sensory nerves easily occurs as a result of the release of vasodilator neuropeptides such as substance P.Such vasodilator responses increase intra-pulpal pressure and disturbvenous blood outflow. Consequently, the dental pulp falls into circulatory disturbance.A sympathetic vasoconstriction system mediated via alpha-adrenoceptors also exists in the dental pulp, whereas a vasodilator system mediated via beta-adrenoceptors is absent.Parasympathetic vasodilator systems are apparently lacking in the dental pulp, although many other tissues in the oro-facial region have these systems. The lack of parasympathetic vasodilatation in the dental pulp may be considered a characteristic feature of the regulation of pulpal blood flow ; it may be beneficial for the dental pulp, with its enclosed and low-compliance system, to avoid circulatory disturbances. (2) We designed a new method for the assessment of human tooth pulp vitality by monitoringpulpal blood flow. Pulpal blood flow is measured by means of a transmitted laser light, which is transmitted from the buccal surface of the tooth and received from the palatalsurface. This apparatus does not assess sensitivity of the dental pulp, but pulp vitality itself. Further, it causes no pain to the patient and is therefore objective. This new system is expected to be useful in the diagnosis of oral diseases.

(1)牙髓富含神经和血管。这些神经和血管彼此密切相关。特别是在牙髓中，这是密集的感觉神经轴突支配，通过感觉神经介导的逆行血管扩张容易发生作为血管扩张神经肽，如P物质的释放的结果。这种血管扩张反应增加牙髓内压力和干扰静脉血流出。因此，牙髓福尔斯陷入循环障碍。牙髓中也存在通过α-肾上腺素受体介导的交感神经血管收缩系统，而不存在通过β-肾上腺素受体介导的血管扩张系统。牙髓中明显缺乏副交感神经血管扩张系统，尽管口面部区域的许多其他组织具有这些系统。牙髓中副交感神经血管舒张的缺乏可以被认为是牙髓血流调节的特征;对于具有封闭和低顺应性系统的牙髓来说，避免循环障碍可能是有益的。(2)我们设计了一种通过监测牙髓血流量来评估人牙髓活力的新方法。牙髓血流量的测量是通过一个传输的激光，这是从牙齿的颊面发送和接收从腭面。该设备不评估牙髓的敏感性，而是评估牙髓活力本身。此外，它不会给患者带来痛苦，因此是客观的。这一新系统有望在口腔疾病的诊断中发挥作用。