Study on the Carcinogenic Potential of JFM Standard Fibrous Materials in F344 Rats after Intraperitoneal Administration.

JFM标准纤维材料对F344大鼠腹腔给药后致癌潜力的研究。

• 批准号: 09670410
• 负责人: ADACHI Shuichi
• 金额: $ 1.66万
• 依托单位: Saitama Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670410/
• 关键词: Man made mineral fiber; Asbestos; Mesothelioma; Carcinogenicity; Whisker; Silicon carbide; Potassium titanate; Ceramic fiber; 人工鉱物繊維; carcinogeuicity; 中皮膜; carcinogenicity; man made mineral fiber; carcinogeni city

Carcinogencity of 12 types of fibrous samples (JFM standard) was evaluated by the incidence of peritoneal mesothelioma in female F344 rats two years after the intraperitoneal administration. Peritoneal mesothelioma were induced in the rats administered silicon carbide whisker (SC), UICC chrysotile B (UC), potassium titanate whisker(PT), ceramic fiber 1(RF 1), ceramic fiber 2(RF2) or aramid fiber(AR). No significant lethal effect and tumor induction was observed in rats exposed to mullite fiber (RF3), wollastonite (WO), rockwool (RW), glasswool (GW), TiO2 whisker (TO) or micro glass fiber (MG). The rat having peritoneal mesothelioma was found easily by the accumulation of bloody ascites. Tumor cells diffused on abdominal wall forming small nodules (1 to 3 mmφ). Adhesive proliferations between diaphragm and liver were observed in most mesothelioma case. There was no metastasis of tumor to remote organ or tissue in any rats. Histopathiogically, sarcomatous type and mixed type were more th … More an the epithelial type. Among these mesotheliomas, 6% showed the osseous differentiation of tumor.Based on these results, we tried to evaluate the carcinogenic potency of man-made fibers in comparison with UC. Because the dose of UC was logarithmically in inverse proportion with 50% survival period (due to mesothelioma), equivalent dose to UC could be calculated by the 50% survival period of SC and PT. When the number and weight ratios of UC, Sc and PT fibers are same, it is estimated that breathing air containing 1.3 X 10ィイD1-6ィエD1 fiber/ml (WHO) or 4×10ィイD1-6ィエD1 fiber/ml (EPA) of asbestos for entire life will result one life time risk for cancer in 1,000,000, identically, 0.5 X 10ィイD1-6ィエD1 fiber/ml (WHO) or 1.7 X 10ィイD1-6ィエD1 fiber/ml (EPA) of SC and 5.7x 10ィイD1-6ィエD1 fiber/ml (WHO) or 1.7x 10ィイD1-6ィエD1 fiber/ml (EPA) of PT have equal risk. On the regulation of working environment, 0.2 fiber/ml of asbestos is the permissible exposure limit (PEL-OSHA) and is equal to 0.09 fiber/ml for SC and 0.90 fiber/ml for PT. Threshold limit value (TLV-ACGIH) is 0.5 fiber/ml for asbestos and the level is equivalent to 0.21 fiber/ml for SC or 2.2 fiber/ml for PT. Less

通过腹腔给药后2年雌性F344大鼠腹膜间皮瘤的发生率评价12种纤维样品（JFM标准）的致癌性。分别用碳化硅晶须（SC）、UICC温石棉B（UC）、钛酸钾晶须（PT）、陶瓷纤维1（RF 1）、陶瓷纤维2（RF 2）和芳纶纤维（AR）诱发大鼠腹膜间皮瘤。莫来石纤维（RF_3）、硅灰石（WO）、岩棉（RW）、玻璃棉（GW）、TiO_2晶须（TO）和超细玻璃纤维（MG）对大鼠无明显的致死作用和致瘤作用。腹膜间皮瘤的大鼠容易通过血性腹水的积累而被发现。肿瘤细胞在腹壁上扩散形成小结节（1 - 3 mm φ）。大多数间皮瘤病例可见膈与肝脏之间的粘连性增生。所有大鼠均未发现肿瘤向远处器官或组织转移。组织病理以肉瘤型和混合型多见， ...更多信息 上皮型。在这些间皮瘤中，6%的间皮瘤表现出肿瘤的骨分化。基于这些结果，我们试图评估与UC相比，人造纤维的致癌潜力。由于UC的剂量与50%生存期（由于间皮瘤）成反比，因此可以通过SC和PT的50%生存期计算UC的等效剂量。当UC、Sc和PT纤维的数量和重量比相同时，估计终生呼吸含有1.3 × 10 - 1D 1 - 6 - 1D 1纤维/ml（WHO）或4 × 10 - 1D 1 - 6 - 1D 1纤维/ml（EPA）石棉的空气将导致1，000，000人中的一个终生癌症风险，相同，SC的0.5 × 10 - 100D1 - 6 - 100D1纤维/ml（WHO）或1.7 × 10 - 100D1 - 6 - 100D1纤维/ml（EPA）与PT的5.7 × 10 - 100D1 - 6 - 100D1纤维/ml（WHO）或1.7 × 10 - 100D1 - 6 - 100D1纤维/ml（EPA）具有相同的风险。关于工作环境的规定，0.2纤维/ml的石棉是允许接触限值（PEL-OSHA），相当于SC的0.09纤维/ml和PT的0.90纤维/ml。石棉的阈值限值（TLV-ACGIH）为0.5纤维/ml，SC的水平相当于0.21纤维/ml，PT的水平相当于2.2纤维/ml。少