Responce properties of charge-controllable membranes sensitive to electrical stimulus and development of bio-material devices

对电刺激敏感的电荷可控膜的响应特性及生物材料器件的开发

• 批准号: 09650843
• 负责人: SUDOH Masao
• 金额: $ 2.43万
• 依托单位: Shizuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09650843/
• 关键词: Charge-controllable membrane; Iontophoresis; Polypyrrol; Ion exchange membrane; Diffusion dialysis; Electro-dialysis; Ion gate; Dopant; 人工すい臓; DDS; ゲル膜; 荷電膜; アミノ酸

An iontophoretic transport of ionic drug across a charge-controllable membrane as a semipermeable membrane was examined experimentally and discussed by using the ionic transport model for an ion-exchange membrane. The iontophoretic transport of L-glutamate across the charge-controllable PPy membrane under the doping and undoping conditions was affected by electric field, the size of dopant anion (small, middle and polymer anions), intramembrane structure (dense and loose). Using PPy^+/C1^- menbrane, ionic flux across the undoped membrane was a little lower than that across the doped membrane. Using PPy^+/PSS^- membrane, ionic flux across the undoped membrane was several times higher than that across the doped membrane. The mode of permeation flux of PPy^+/MA^-( loose) for doping and undoping behave as a porous membrane of neutral charges for undoping, the flux across the undoped membrane was considered to become larger than that across the doped one.

用离子交换膜的离子迁移模型对离子型药物在电荷可控膜中的迁移进行了实验研究和讨论。在掺杂和未掺杂条件下，L-谷氨酸通过电荷可控聚吡咯膜的电迁移受电场、掺杂阴离子（小阴离子、中阴离子和高分子阴离子）、膜内结构（致密和疏松）的影响。使用PPy^+/Cl ^-膜时，未掺杂膜的离子通量略低于掺杂膜。使用PPy^+/PSS^-膜，穿过未掺杂膜的离子通量比穿过掺杂膜的离子通量高出数倍。PPy^+/MA^-（松散）的渗透通量在掺杂和未掺杂时表现为中性电荷的多孔膜，未掺杂膜的渗透通量大于掺杂膜。

项目成果

須藤雅夫: "環境工学" 槇書店, 245 (1997)

须藤正雄：《环境工程》牧书店，245（1997）

須藤雅夫: "皮下組織内グルコース濃度の計測のためのマイクロダイアリシス・プローブの物質移動特性" 化学工学論文集. 24・2. 228-232 (1998)

Masao Sudo：“用于测量皮下组织中葡萄糖浓度的微透析探针的传质特性”化学工程学报24・2（1998）。

須藤雅夫: "イオン交換膜の不均質膜内構造と輸送特性" J.Ion Exchange. 8・4. 202-213 (1997)

Masao Sudo：“离子交换膜的异质膜内结构和传输特性”J.Ion Exchange 8・4（1997）。

M.Sudoh and E.Inami: "Measurement of dynamic transport number in ion-exchange membrane by using limiting current technique with microhole filter" J.Sea Water Soc.52. 359-366 (1998)

M.Sudoh 和 E.Inami：“使用微孔过滤器的限流技术测量离子交换膜中的动态传输数”J.Sea Water Soc.52。

M.Sudoh, A.Mori et al.: "Development of novel micro-sensor of disposable chips with oxygen enrichment by pre-electrolysis for monitoring blood glucose" Electrochem.Acta. to be printed.

M.Sudoh、A.Mori 等人：“开发新型一次性芯片微传感器，通过预电解富氧监测血糖”Electrochem.Acta。