High throughput SECM imaging: Development and applications

EPFL的分析和物理电化学实验室（LEPA）和Oldenburg大学（UOL）的凝聚态物质界面和电化学实验室之间的联合资助申请的目的是将前者的器件微细加工专业知识与后者的仪器设计和数据处理联合收割机结合起来，以开发扫描电化学显微镜（SECM）的新概念。其具体目的是对现有技术无法实现的大区域进行成像。本建议的要点是设计，制造和测试的微加工软Tipp阵列的并行记录的32线图像每次扫描。这种新的方法将特别用于蛋白质分离和/或其各自的印迹中使用的银染2D凝胶的图像。同样，它还将用于进一步发展最近与洛桑大学法医科学实验室合作开发的指纹成像技术。我们还将应用它来研究溴生成的表面改性，并测试技术涂层的缺陷。在第二阶段，我们希望开发一种新的软尖概念，具有内置的微通道，以便对干燥的基材进行成像，电解质在尖端输送，就像钢笔尖端的墨水一样。这也将不仅用于成像干燥样品的表面反应性，如腐蚀的金属，但也选择性地蚀刻表面，目的是图案化它们或通过电沉积或电接枝在干燥表面上书写。

The aim of this combined grant application between the Laboratory of Analytical and Physical Electrochemistry (LEPA) from EPFL and the laboratory Condensed Matter Interfaces and Electrochemistry from Oldenburg University (UOL) is to combine the device microfabrication expertise of the former and the instrument design and data processing of the latter to develop new concepts in Scanning ElectroChemical Microscopy (SECM) with the specific aim to image large area that cannot performed with the existing technology. The gist of this proposal is the design, fabrication and tests of micro-machined soft Tipp arrays for the parallel recording of a 32-line image per scan. This novel methodology will be used in particular to image silver-stained 2D gels used in protein separation, and/or their respective blots. Similarly, it will also be used to develop further the fingerprint imaging technology recently developed in collaboration with the Forensic Science Laboratory at the University of Lausanne. We shall apply it also to study the surface modification by bromine generation, and to test technical coatings for defects. In a second stage, we would like to develop a new soft-tip concept with built-in microchannels so as to image dry substrates, the electrolyte being delivered at the tip like the ink at the tip of a fountain pen. This will also be used not only to image the surface reactivity of dry samples such as corroded metals but also to etch selectively surfaces with the aim to pattern them or to write on dry surfaces by electrodeposition or electrografting.