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Project for development of in vivo rat model internal 131-iodine exposure in thyroid grand

甲状腺内 131 碘暴露体内大鼠模型开发项目

基本信息

批准号：
09558072
负责人：
YAMASHITA Shunichi
金额：
$ 5.7万
依托单位：
Nagasaki University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09558072/
关键词：
Thyroid tumor Radiation Iodine-131 Animal Model 動物モデル甲状腺がん内部被ばく

项目摘要

After Chernobyl disaster at 1986, the number of childhood thyroid cancer increased there. We were joining the Chernobyl Sasakawa Health and Medical Cooperation Project form 1991 to 1996. We screened more than 13000 children during 5 years. The incidence of childhood thyroid cancer is 100 times higher than Japan. Unfortunately, we did not have the data about the direct thyroid dosimetory of these patients at the time of the accident. The direct relationship between radiation and thyroid cancer is still uncertain. On the other hand, previous reports showed no increase of thyroid cancer among patients who were diagnosed or treated using Iodine-131. To elucidate whether radio-iodine intake cause thyroid cancer, we have tried to make animal model that is internally exposed by Iodine-131. Iodine-131(0, 0.2, 0.6, 1Mbq) was peritoneally injected to rats that previously took low iodine diets (n=10/each group). One, two, six or twelve months after radiation exposure, rats were sacrificed and analyzed pathophigiologically. We observed no increase of thyroid tumor among exposed rats. The result does not lead to any concrete conclusions because the number of examined rats is not good enough to statistically analyze. Furthermore, we speculate that rat spicies and their ages relate to sensitivity to cause thyroid tumors following radiation exposure. In future, we win further examine to answer the relationship between thyroid cancer and Iodine-131 exposure.

1986 年切尔诺贝利灾难后，那里的儿童甲状腺癌人数有所增加。 1991年至1996年，我们参加了切尔诺贝利笹川健康和医疗合作项目。5年间，我们对13000多名儿童进行了筛查。儿童甲状腺癌的发病率比日本高100倍。不幸的是，我们没有事故发生时这些患者的直接甲状腺剂量的数据。辐射与甲状腺癌之间的直接关系仍不确定。另一方面，之前的报告显示，使用 Iodine-131 诊断或治疗的患者中，甲状腺癌的发病率并未增加。为了阐明摄入放射性碘是否会导致甲状腺癌，我们尝试制作了Iodine-131内照射的动物模型。将Iodine-131(0, 0.2, 0.6, 1Mbq)腹腔注射给先前接受低碘饮食的大鼠(n=10/每组)。辐射暴露后一、二、六或十二个月，处死大鼠并进行病理学分析。我们观察到暴露的大鼠中甲状腺肿瘤没有增加。该结果并不能得出任何具体结论，因为受检大鼠的数量不足以进行统计分析。此外，我们推测大鼠的香料及其年龄与辐射暴露后引起甲状腺肿瘤的敏感性有关。未来，我们将进一步研究甲状腺癌与碘131暴露之间的关系。