Genetic alteration, angiogenesis and stromal proliferation related to the development and metastasis of gastric cancer

我们检测了胃癌组织中p53 - VEGF的表达，并解释了部分与血管生成有关的各种因素。淋巴、血管受累及淋巴结转移率高，p53、VEGF染色阳性，预后最差。突变型p53的表达导致VEGF的表达，刺激血管生成，增加肿瘤微血管密度（MVD），促进胃癌的浸润和转移。探讨粘膜下胃癌（分为Pen a型、Pen B型和未分类型）的生长发育、MVD与VEGF表达的关系。Pen A型血管内皮生长因子（VEGF）阳性率和MVD升高明显高于其他类型。Pen A型的5年存活率低于Super型。Pen A型复发病例均为VEGF高表达。多因素研究结果表明，VEGF的表达与淋巴受累一样是重要的预后因素。在胃癌的早期发展中，Pen A型可估计容易产生VEGF，刺激血管生成，导致血管受累。因此，人们认为Pen A型因血液转移而复发率高，预后差。探讨TGF-β1与胃癌的关系。胃癌原发肿瘤TGF-β1阴性的转移淋巴模式中，TGF-β1染色阳性的占54.2%。TGF-β1与胃癌的侵袭转移密切相关。

We examined the expression of p53 VEGF in the gastric cancer organization and the part of the various factors in relation to the angiogenesis had been explained. The rate of the presence of lymphatic and vascular involvement and lymph node metastasis was high in their cases which showed positive finding of mutant p53 and VEGF staining and were the poorest prognosis. The case that the expression of mutant p53 led the expression of VEGF, stimulated the angiogenesis, was increased the microvessel density (MVD) in the tumor and prompted the infiltration and metastasis of the gastric cancer.It was examined about the relations between the growth development from the tumor, (which was classified as a Pen A type, a Pen B type and the unclassified type), MVD and the expression of VEGF in submucosal gastric cancer. For Pen A Type, the positive rate of VEGF and increased MVD was significantly higher than other forms. 5 years survival rate of Pen A type is lower as compared with it of Super type. All of recurrent cases in Pen A type was hyper expression of VEGF. As a result of multivariate studies, the expression of VEGF was significant prognostic factor as same as lymphatic involvement. In the initial development of the gastric cancer, Pen A type could be estimated to be easy to produce VEGF, stimulate angiogenesis and lead to vascular involvement. For that reason, it was thought that Pen A type showed high rate of recurrent due to hematogenous metastasis and poor prognosis. It was examined about relation between TGF-β1 and gastric cancer. Metastatic lymph modes of gastric carcinomas with a TGF-β1 negative primary tumor were positive for TGF-β1 staining in 54.2%. TGF-β1 is closely related to the invasion and metastasis of gastric cancer.