A novel treatment strategy for digestive system cancer against angiogenic signal in tumor stroma using nanosize particle.

使用纳米粒子对抗肿瘤基质中血管生成信号的消化系统癌症的新治疗策略。

• 批准号: 21249072
• 负责人: MAEHARA Yoshihiko
• 金额: $ 31.03万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21249072/
• 关键词: 腫瘍血管新生; PLGAナノ粒子; PDGFα受容体; ラパマイシン; 虚血; ラバマイシン

We have developed a novel treatment strategy against tumor vascular endothelium using nanosize particle encapsulated rapamycin. Inhibiting the signaling PDGF-AA/PDGFRα/p70S6K, the tumor angiogenesis was remarkably restricted, which result in significant antitumor effect. The same observation was recognized in vivo analysis of subcutaneous colon tumor model and liver metastatic colon tumor model. These drug delivery system, using PLGA nanosize particle which affect tumor ischemic region suggested that it might be possible to break out the paradigm of anti-angiogenic treatment. To conduct a clinical test, we have a plan to produce nanosize particle based on Good Manufacturing Practice and to perform a clinical safety study.

我们开发了一种利用纳米颗粒包裹雷帕霉素来治疗肿瘤血管内皮细胞的新策略。抑制PDGFAA/PDGFFRα/p70S6K信号通路，可显著抑制肿瘤血管生成，从而发挥显著的抗肿瘤作用。在皮下结肠癌模型和肝转移结肠癌模型的体内分析中也发现了相同的观察结果。这些利用PLGA纳米颗粒影响肿瘤缺血区的药物传递系统，提示有可能突破抗血管生成治疗的范式。为了进行临床测试，我们计划根据良好的制造规范生产纳米颗粒，并进行临床安全性研究。

项目成果

Results of a surgical resection of pulmonary metastasis from malignant head and neck tumor

• DOI: 10.1510/icvts.2009.219766
• 发表时间: 2010-05-01
• 期刊: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
• 作者: Haro, Akira;Yano, Tokujiro;Maehara, Yoshihiko
• 通讯作者: Maehara, Yoshihiko

Intracellular delivery of serum-derived hepatitis C virus.

• DOI: 10.1016/j.micinf.2011.01.005
• 发表时间: 2011-04
• 期刊: Microbes and infection
• 影响因子: 5.8
• 作者: Fukuhara T;Tani H;Shiokawa M;Goto Y;Abe T;Taketomi A;Shirabe K;Maehara Y;Matsuura Y
• 通讯作者: Matsuura Y

Iron state in association with retinoid metabolism in non‐alcoholic fatty liver disease

• DOI: 10.1111/j.1872-034x.2010.00719.x
• 发表时间: 2010-12
• 期刊: Hepatology Research
• 影响因子: 4.2
• 作者: H. Tsuchiya;An Afida Ashla;Y. Hoshikawa;Yoshiaki Matsumi;K. Kanki;M. Enjoji;S. Momosaki;M. Nakamuta;A. Taketomi;Y. Maehara;K. Shomori;A. Kurimasa;I. Hisatome;Hisao Ito;G. Shiota

Long-Term Results of Hepatic Resection Combined with Intraoperative Local Ablation Therapy for Patients with Multinodular Hepatocellular Carcinomas

• DOI: 10.1245/s10434-009-0721-0
• 发表时间: 2009-12-01
• 期刊: ANNALS OF SURGICAL ONCOLOGY
• 影响因子: 3.7
• 作者: Itoh, Shinji;Morita, Kazutoyo;Maehara, Yoshihiko
• 通讯作者: Maehara, Yoshihiko

Systemic MCP1/CCR2 blockade and leukocyte specific MCP1/CCR2 inhibition affect aortic aneurysm formation differently

• DOI: 10.1016/j.atherosclerosis.2010.01.042
• 发表时间: 2010-07-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: de Waard, Vivian;Bot, Ilze;van Berkel, Theo J. C.
• 通讯作者: van Berkel, Theo J. C.