A novel treatment strategy for digestive system cancer against angiogenic signal in tumor stroma using nanosize particle.

我们已经开发了一种新的治疗策略，对肿瘤血管内皮细胞使用纳米颗粒包裹雷帕霉素。通过抑制PDGF-AA/PDGFRα/p70 S6 K信号通路，可显著抑制肿瘤血管生成，具有显著的抗肿瘤作用。在皮下结肠肿瘤模型和肝转移性结肠肿瘤模型的体内分析中认识到相同的观察结果。这些药物传递系统，使用PLGA纳米颗粒，影响肿瘤缺血区表明，它可能会打破抗血管生成治疗的范式。为了进行临床试验，我们计划根据良好生产规范生产纳米颗粒，并进行临床安全性研究。

We have developed a novel treatment strategy against tumor vascular endothelium using nanosize particle encapsulated rapamycin. Inhibiting the signaling PDGF-AA/PDGFRα/p70S6K, the tumor angiogenesis was remarkably restricted, which result in significant antitumor effect. The same observation was recognized in vivo analysis of subcutaneous colon tumor model and liver metastatic colon tumor model. These drug delivery system, using PLGA nanosize particle which affect tumor ischemic region suggested that it might be possible to break out the paradigm of anti-angiogenic treatment. To conduct a clinical test, we have a plan to produce nanosize particle based on Good Manufacturing Practice and to perform a clinical safety study.