Ion Selective Transport Across Liquid Membrane Mimicking Renal Tubule Function

为了进一步改善人工肾的血液透析治疗，需要开发一种新的肾小管系统，该系统只从血液中清除尿毒症毒素，或从透析液中回收必要的离子和溶质并将其返回血液。本研究的目的是分离离子(Na+，Cl^-)和尿素，并从透析液中回收离子。以电势差为驱动力，利用离子选择液膜分离离子(Na~+、Cl~-)和尿素，并通过透析浓缩离子。用浸渍有机溶液的聚四氟乙烯膜作为液膜，在有机溶液中形成反胶束或溶解络合物。采用反胶束液膜时，Na+和Cl2-的迁移速率高于尿素，并随电位差的增大而增大。使用螯合液膜时，膜的稳定性高于反胶束液膜。在…上另一方面，在不施加电位差的情况下，Na~+和Cl~-在液膜中的渗透速度与尿素一样快。然后利用反胶束液膜设计了模拟电渗析装置的三室间歇电池。当外加电位差作为驱动力时，中间细胞内的Na+和Cl2-浓度增加，而尿素浓度保持不变。因此，采用三室间歇反胶束液膜分离NaCI和尿素溶液中的离子(Na+，Cl^-)和浓缩离子(Na+，Cl^-)是可行的，可以模拟肾小管的功能，从流出的透析液中回收必需的离子和溶质回到血液中。较少

Further improvement of hemodialysis treatments with artificial kidney requires the development of a new renal tubule system that removes only uremic toxins from the blood, or recovers essential ions and solutes from outfiowing diatysate and returns them to the blood.The objective of the present study is to separate ions (Na^+, Cl^-) and urea and to recover the ions from the outfiowing dialysate. A potential difference was applied as a driving force using an ion selective liquid membrane to separate ions (Na^+, Cl^-) and urea and to concentrate the ions by dialysis. A PTFE membrane, impregnated with an organic solution in which reversed micelles were formed or chelate was dissolved was used as a liquid membrane. Using a reversed micelle liquid membrane, the transfer rate of Na^+ and Cl^- was higher than that of urea, and increased by applying the potential difference. Using a chelate liquid membrane, its membrane stability was higher than that of the reversed micelle liquid membrane. On … More the other hand, when no potential difference was applied, Na^+ and Cl^- permeated across the liquid membrane as fast as urea. Then a three chambers batch cell mimicking an electrodialysis apparatus was devised using the reversed micelle liquid membrane. When a potential difference was applied between outside two chambers as a driving force, Na^+ and Cl^- concentrations in the middle cell increased and urea concentration was kept to be constant. Therefore, repeated operation or continuous operation with the same cells connected makes it possible to separate ions (Na^+, Cl^-) and urea and concentrate ions (Na^+, Cl^-) efficiently.In conclusion, separation of ions (Na^+, Cl^-) and urea and concentration of ions (Na^+, Cl^-) in NaCI and urea solution with the three chambers batch cell are feasible using the reversed micelle liquid membrane, and the function of the renal tubule can be modeled and essential ions and solutes can be recovered from outflowing dialysate and returned to the blood. Less