Influence of herpesvirus in infection/reactivation to AIDS

对227名母亲为人类免疫缺陷病毒(HIV)阳性母亲所生的儿童进行了人类疱疹病毒6型(HHV6)感染的调查。在41名HIV感染的婴儿中，3名(7%)在出生后1个月时HHV6DNA阳性。表明可能是宫内感染。HIV感染者6个月和12个月的累积感染率(分别为11%和33%)显著低于未感染者(28%和78%)。分别为P&lt；.001)。HHV6感染前的高CD4+细胞数(15%)与高HHV6感染率之间存在关联。对22名被归类为疾病控制和预防中心N1或N2期的艾滋病毒婴儿进行了研究，以确定HHV6感染与艾滋病毒疾病进展的关系。其中10名婴儿感染了HHV6，12名没有。在没有感染HHV6的婴儿中，有5名(42%)在1岁时艾滋病毒疾病没有进展；然而，在所有10名感染HHV6的儿童中，艾滋病毒疾病都有进展。The…更多的SES结果表明，在研究儿童中，HHV6感染与HIV疾病的进展与垂直HIV1感染有关(P&lt；0.05)。(J.Infect.人免疫缺陷病毒1型(HIV1)携带者是否患有皮肤病，以及泰国HIV1阴性者的血清阳性率。经IFA检测，有皮肤病和无皮肤病的HIV1携带者对KSHV/HHV8裂解抗原的血清阳性率分别为25%和7.4%，而HIV1阴性个体和抗体均为阴性。在低CD4/CD8比值的HIV阳性个体中，KSHV/HHV8抗原的血清阳性率很高，提示KSHV/HHV8在免疫抑制状态下被重新激活。我们的结果表明，在HIV1携带者中，KSHV/HHV8与HIV共存，HHV8的存在可能与皮肤的特征有关。用KSHV/HHV8的特异性抗体对vIRF(K9)基因及其产物进行了鉴定。VIRF是一个早期在细胞核中表达的基因，功能上针对细胞内的IRF1，提示vIRF可能参与了Kaposi肉瘤的形成。R2重复数是一个很好的识别传播来源的标记。另一方面，糖蛋白H(Gh)和糖蛋白B(Gb)在15个分离物中具有较高的相似性，表明这些结构基因不适合作为亚型标记。较少

The role of human herpesvirus 6 (HHV6) infection in 227 children born to human immunodeficiency virus (HIV)-seropositive mothers was investigated. Of 41 HIV-unifected infants, 3(7%) were positive for HHV6 DNA in the first morth of life. suggesting possible intrauterine infection. The cumulative infection rates of HHV6 at 6 and 12 months of age were significantly lower in HIV-infected children (11% and 33%, respectively) than in uninfected children (28% and 78%. respectively ; P<.001). There was an association between high CD4+ cell numbers (>15%) before HHV6 infection and high HHV6 infection rate. Twenty two infants with HIV classed as Centers for Disease Control and Prevention stages N1 or N2 were studied for an association of HHV6 infection with progression of HIV disease. Ten of the infants had HHV6, and 12 did not. In 5 of the infants without HHV6 (42%), HIV disease had not progressed by 1 year of age ; however, HIV disease had progressed in all 10 children with HHV6 infection. the … More ses results suggest an association of HHV6 infection and progression of HIV disease in the study children with vertical HIV1 infection (P<.05). (J.Infect. Disease, 180 : 50-55, 1999)The seroprevalence to Kaposi's sarcoma-assocciated herpesvirus (KSHV) or human herpesvirus8 (HHV8) was surveyed in human immunodeficiency virus type 1 (HIV1) carriers with or without skin diseases, and also in HIV1 negative individuals in Thailand. With IFA, the seropositive rates to lytic antigens of KSHV/HHV8 in HIV1 carriers with or without skin diseases were 25% and 7.4%, respectively, but none of HIV1 negative individuals ahd antibody. The seroprevalence to KSHV/HHV8 antigens was high in HIV positive individuals with low CD4/CD8 ratio, suggesting that KSHV/HHV8 is reactivated during the immunosuppressive state. Our results suggested that KSHV/HHV8 co-existed with HIV in HIV1 carriers and the existence of HHV8 may be associated with features in the skin.vIRF (K9) gene and its product was characterized by using a specific antibody against vIRF of KSHV/HHV8. vIRF was an early gene expressed in the nucleus and functionally worked against the cellular IRF1, suggesting that vIRF may be involved in Kaposi's sarcoma tumor formation.R2 repeat of HHV7 was characterized and analyzed to verify the transmission status. R2 repeat number was proved to be a good marker for the identification of the origin of transmission. On the other hand, glycoprotein H (gH) and glycoprotein B (gB) showed high similarity among fifteen isolates, suggesting that these structural genes were not suitable for the subtype marker. Less