NEW OILY AGENTS FOR TARGETING CHEMOTHERAPY FOR HEPATOCELLULARCARCINOMA

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Evaluation of new oily agents for targeting chemoembolization for hepatocellular carcinomais aim of this study. Five kinds of oil preparations were injected into the hepatic artery of 54 rabbits inoculated with VX2 carcinomacells in order to evaluate (1) the safty of these preparations, (2) their histological distribution and the amounts of agents remaining at tumor sites, and (3) CT images obtained. Of these preparations, three were made by mixing non-iodinated poppy seed oil and a thicker and then adjusted to have a viscosity lower than, equal to, or higher than of lipiodol. A fourth preparation was a mixture of lipiodol and a thickener with higher viscosity than lipiodolalone, and the fifth preparation was lipiodolalone.Results below was obtained : (1) No injury to the hepatic parenchyma was obtained hematologicallyor historogically. (2) With increase in the viscosity, a significant larger amount of agent remained at the tumor site. No agent was present at normal sites 14 days after intraarterial injection, regardless of which preparation was given. (3) On CT scans following intra-arterial injection, tumor cell was visibly deeply stained in the non-iodinated preparation groups, while the lipiodol groups were not evaluate because of excessively high attenuation.In conclusion, The non-iodinated oily preparations and highly viscous oily preparations developed in the present study were more useful than lipiodol for treatment of hepatic tumors