Development of a new drug candidate to stimulate bone formation by oligomerization of RANKL-binding peptides
Development of a new drug candidate to stimulate bone formation by oligomerization of RANKL-binding peptides
批准号:
25293377
负责人:
AOKI Kazuhiro
金额:
$11.4万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2013
资助国家:
日本
项目状态:
已结题
起止时间:
2013-04-01 至 2016-03-31
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Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity.
用核因子 - κB配体(RANKL)结合肽的受体激活剂治疗的小鼠的皮质骨刺激骨形成,该肽具有破骨构成抑制活性。
DOI:
10.1074/jbc.m112.426080
发表时间:
2013-02-22
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
[Furuya Y, Inagaki A, Khan M, Mori K, Penninger JM, Nakamura M, Udagawa N, Aoki K, Ohya K, Uchida K, Yasuda H]
通讯作者:
Yasuda H
An Osteoprotegerin-like Peptide Inhibits Bone Loss in Collagen Type II-Induced Murine Arthritis.
骨保护素样肽可抑制 II 型胶原蛋白诱导的小鼠关节炎中的骨质流失。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kato, G. Maeda, M. Alles, N. Mamun, A. Khan, M. Sugamori, Y. Takahashi, M. Tamura, Y. Murali, R. Ohya, K. Aoki, K.]
通讯作者:
K.
RANKL結合ペプチドの軟骨細胞分化促進と軟骨破壊抑制作用
RANKL 结合肽促进软骨细胞分化并抑制软骨破坏
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[菅森 泰隆, 加藤 玄樹, 田村 幸彦, 大谷 啓一, 青木 和広.]
通讯作者:
青木 和広.
NanoClikナノ粒子のペプチド除法性の検討―NanoClikナノ粒子がW9の骨吸収抑制作用を助けるメカニズム―
NanoClik纳米颗粒的肽去除特性研究 - NanoClik纳米颗粒帮助W9骨吸收抑制作用的机制 -
DOI:
--
发表时间:
2015
期刊:
影响因子:
--
作者:
[佐藤俊三, 田村幸彦, 大谷啓一, 青木和広.]
通讯作者:
青木和広.
The bone resorption inhibitor peptide promotes bone formation by a reverse signaling pathway.
骨吸收抑制肽通过反向信号传导途径促进骨形成。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Aoki, K.]
通讯作者:
K.
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