A new plant-derived flukicide: increased farm profitability and reduced carbon footprint by overcoming losses caused by existing flukicide resistance

一种新型植物源杀吸虫剂：通过克服现有杀吸虫剂抗性造成的损失，提高农场盈利能力并减少碳足迹

• 批准号: 10003793
• 金额: $ 48.92万
• 依托单位: RIDGEWAY RESEARCH LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10003793
• 关键词: new; plant; derived; flukicide; increased

Liver fluke (LF) infections in cattle/sheep are a major economic problem for farmers, and an animal welfare issue. Resistance to current drugs is growing rapidly worldwide, and there are few new drugs in development. Resistance reduces milk-yield and extends the time-to-market for meat, leading to significant additional methane production.Common ivy contains a molecule that partly controls LF in sheep. This project will optimise its effect, developing a drug that efficiently controls LF and overcomes resistance, creating a supply chain from cultivating ivy to a livestock treatment. This would increase feed-use efficiency, improve animal welfare and reduce greenhouse gas production.

牛/羊的肝吸虫（LF）感染是农民的主要经济问题，也是动物福利问题。对目前药物的耐药性在世界范围内迅速增长，几乎没有新药在开发中。抵抗力降低了产奶量，延长了肉类上市的时间，导致大量额外的甲烷产生。普通常春藤含有一种分子，可以部分控制绵羊的LF。该项目将优化其效果，开发一种有效控制LF并克服耐药性的药物，建立从种植常春藤到牲畜治疗的供应链。这将提高饲料使用效率，改善动物福利并减少温室气体的产生。