Neurovascular pericytes in development and brain regeneration

发育和脑再生中的神经血管周细胞

• 批准号: DP210102712
• 负责人: Prof Benjamin Hogan
• 金额: $ 46.75万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-04-27 至 2024-04-26
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102712
• 关键词: Neurovascular; pericytes; development; brain; regeneration

The brain is responsible for a quarter of the body’s metabolism and is thus perfused by an extensive network of blood vessels. Pericytes surround these vessels and interact with neurons, glia, immune cells and neural stem cells of the neurovascular unit. Pericytes influence brain development, function and regeneration but remain enigmatic. This project investigates molecular control of pericyte development, functional coupling of pericytes with adjacent cells and pericyte function in tissue regeneration. We aim to produce new fundamental knowledge in brain development, structure, function and evolution. New knowledge generated here may lead to future approaches in stem cell biology, tissue engineering, regeneration and ageing of the brain.

大脑负责人体四分之一的新陈代谢，因此由广泛的血管网络灌输。周细胞包围这些血管，并与神经血管单位的神经元、神经胶质细胞、免疫细胞和神经干细胞相互作用。周细胞影响大脑的发育、功能和再生，但仍是个谜。本项目研究周细胞发育的分子调控、周细胞与相邻细胞的功能偶联以及周细胞在组织再生中的作用。我们的目标是在大脑发育、结构、功能和进化方面产生新的基础知识。这里产生的新知识可能会导致未来在干细胞生物学、组织工程、大脑再生和衰老方面的方法。