cell-cell adhesive force in vascular development

血管发育中的细胞间粘附力

• 批准号: DP150104119
• 负责人: Prof Benjamin Hogan
• 金额: $ 30.86万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104119
• 关键词: cell; adhesive; force; vascular; development

This project aims to utilize groundbreaking new approaches to visualize cell-cell adhesive forces in vascular development. Vascular system development is one of the earliest events in the vertebrate embryo. It has long been established that one major contributor to the formation of new vessels is physical force, which can be generated through blood flow or cell-cell interactions during tissue morphogenesis. The project plan utilizes live imaging in zebrafish and a new generation of biosensors to gain a vastly deeper understanding of how force controls vessel formation.

该项目旨在利用突破性的新方法来可视化血管发育中的细胞-细胞粘附力。血管系统的发育是脊椎动物胚胎中最早的事件之一。长期以来已经确定，形成新血管的一个主要因素是物理力，其可以通过组织形态发生期间的血流或细胞-细胞相互作用产生。该项目计划利用斑马鱼和新一代生物传感器的实时成像，以更深入地了解力如何控制血管形成。