Hippo signalling control of transcription in lymphatic vascular development

河马信号控制淋巴管发育中的转录

• 批准号: DP240101588
• 负责人: Prof Benjamin Hogan
• 金额: $ 72.06万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101588
• 关键词: Hippo; signalling; control; transcription; lymphatic

Lymphatic vasculature forms complex, branched networks present in almost all vertebrate tissues and organs. Signalling in lymphatic endothelial cells determines the fate, structure and function of these complex and essential networks. This project follows our recent discovery of a major role for the Hippo signalling pathway in lymphatic vascular development. It aims to investigate how Hippo signalling regulates essential target genes that drive lymphatic development. The project expects to generate fundamental knowledge in vascular signalling, transcription and the control of vascular network growth and expansion. Outcomes may provide significant benefits in new approaches in stem cell biology, tissue engineering and regenerative biology.

淋巴血管系统形成复杂的分支网络，存在于几乎所有脊椎动物的组织和器官中。淋巴内皮细胞的信号传导决定了这些复杂而重要的网络的命运、结构和功能。该项目遵循我们最近发现的Hippo信号通路在淋巴管发育中的主要作用。它的目的是研究河马信号如何调节驱动淋巴发育的基本靶基因。该项目希望在血管信号、转录和血管网络生长和扩张的控制方面产生基础知识。结果可能为干细胞生物学、组织工程和再生生物学的新方法提供显著的益处。