Defining the origin of a cell lineage that surrounds and cleans the brain

定义围绕和清洁大脑的细胞谱系的起源

• 批准号: DP200101668
• 负责人: Prof Benjamin Hogan
• 金额: $ 45.5万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101668
• 关键词: Defining; origin; cell; lineage; surrounds

The vertebrate brain is responsible for up to a quarter of the body’s metabolism, a metabolic load that produces large amounts of tissue waste and requires an efficient cleaning system. A recent discovery in zebrafish and preliminary data has uncovered a cell type surrounding the brain that derives from vasculature. These cells play fundamental roles in scavenging and clearing tissue wastes. The project aims to investigate the origins and control of this cell type in zebrafish and mouse brains. This will produce new knowledge in brain development, cellular composition, structure, function and evolution. Outcomes are expected to generate new approaches in stem cell biology, tissue engineering, regeneration and ageing of the brain.

脊椎动物的大脑负责高达四分之一的身体新陈代谢，这是一种代谢负荷，会产生大量的组织废物，需要有效的清洁系统。最近在斑马鱼中的一项发现和初步数据揭示了大脑周围的一种细胞类型，这种细胞类型来自血管系统。这些细胞在清除和清除组织废物方面发挥着基础性作用。该项目旨在调查斑马鱼和老鼠大脑中这种细胞类型的起源和控制。这将在大脑发育、细胞组成、结构、功能和进化方面产生新的知识。这些成果有望在干细胞生物学、组织工程、大脑再生和衰老方面产生新的方法。