Control of vascular form and fate by a novel pre-mRNA splicing mechanism

通过新型前mRNA剪接机制控制血管形态和命运

• 批准号: DP230101541
• 负责人: Prof Benjamin Hogan
• 金额: $ 34.7万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101541
• 关键词: Control; vascular; form; fate; novel

Vertebrate vasculature forms elaborate, branched networks essential for life. As developing vessels permeate tissues and organs, dynamic and spatiotemporally regulated cellular signalling determines the fate, patterning and distribution of new vascular networks. This project follows the recent discovery of a mechanism whereby RNA diversification through alternative splicing controls complex signalling patterns in forming vessels. This project investigates this molecular mechanism in embryo and tissue development. The project will produce fundamental knowledge in RNA diversification, vascular fate, growth and cell signalling. New knowledge generated may lead to new approaches in stem cell biology, tissue engineering and regenerative biology.

脊椎动物的脉管系统形成了生命所必需的复杂的分支网络。随着发育中的血管渗透到组织和器官中，动态和时空调节的细胞信号传导决定了新血管网络的命运、模式和分布。该项目遵循最近发现的一种机制，即RNA多样化通过选择性剪接控制复杂的信号模式形成船只。该项目研究了胚胎和组织发育中的分子机制。该项目将产生RNA多样化，血管命运，生长和细胞信号传导的基础知识。产生的新知识可能会导致干细胞生物学，组织工程和再生生物学的新方法。