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Socioeconomic Mediators of Adult Brain Network Resilience and Vulnerability to Cognitive Decline

成人大脑网络弹性和认知能力下降的社会经济中介因素

基本信息

批准号：
10152485
负责人：
Gagan S Wig
金额：
$ 59.83万
依托单位：
UNIVERSITY OF TEXAS DALLAS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10152485
关键词：
Adult Age Age-associated memory impairment Aging Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease risk Amyloid beta-Protein Atrophic Behavioral Biological Biological Markers Brain Brain imaging Buffers Chronic Climacteric Clinical Cognition Cognition Disorders Cognitive Collection Communities Data Data Collection Dementia Diet Disadvantaged Ecological momentary assessment Environment Environmental Risk Factor Event Exercise Exhibits Exposure to Frequencies Genetic Genetic Markers Genetic Risk Health Impaired cognition Individual Individual Differences Inflammatory Life Life Style Link Longevity Measurement Measures Mediating Mediator of activation protein Moods Neurofibrillary Tangles Neurosecretory Systems Pattern Physical activity Population Prevalence Psyche structure Research Resources Rest Risk Sampling Senile Plaques Social Interaction Socialization Socioeconomic Status Stress Structure Surveys System Testing Time Well in self Work age related age related neurodegeneration allostatic load apolipoprotein E-4 base cardiometabolism carrier status clinical Diagnosis cognitive ability cognitive function critical period dementia risk disease diagnosis early detection biomarkers experience individual variation long term memory low socioeconomic status middle age physical conditioning programs psychosocial recruit relating to nervous system resilience scaffold segregation sleep quality smartphone Application socioeconomics stressor

项目摘要

PROJECT SUMMARY Adult aging is typically accompanied by cognitive decline, as early as middle-age and even in the absence of diagnosed disease. The risk of both middle-age decline and older-age dementia are not randomly distributed across the population. Lower socioeconomic status (SES) is a risk factor for Alzheimer’s disease (AD), likelihood of exhibiting poorer cognition in middle-age, and greater cognitive decline across age. However, even under similar conditions some individuals seem to age with resilience, exhibiting minimal cognitive decline through many years of adulthood, while others experience rapid and early declining cognition. This suggests there are underlying factors that modify or buffer an individual's elevated risk for cognitive decline even in disadvantaged environments. To understand these individual differences, the present project will recruit middle-age adults (40-59 years) from lower- to middle-class SES, and measure their brain and changes in cognitive ability prior to any late stage clinical events. Each individual’s functional brain network will be measured using non-invasive functional brain imaging (while subjects are at rest and during various tasks). An important measure of brain network organization (system segregation), which varies with age, cognition, and SES, will be examined to determine whether it can predict an individual’s cognitive decline over the subsequent 3.5 years (measured over 3 occasions). Critically, measures quantifying distinct features that are presumed to vary across SES (including biological markers of stress (allostatic load), and measures of environment and lifestyle) will also be collected 3 times over 3.5 years. These measurements will be incorporated into analyses to determine how they interact with both brain network organization, and the interaction between network organization and subsequent cognitive decline. Data collection will include bio-specimen samples for assessing cardio- metabolic, neuroendocrine, and inflammatory function, as well as extensive measurement of environments, lifestyle, and psychosocial function. The latter includes alternate-day surveys (ecological momentary assessment) of mood, diet quality, sleep quality, exercise frequency, and social interaction (administered using a smart-phone application). Our primary aims involve: (1) identifying mediators between an individual’s SES and their brain network organization, (2) examining brain network organization as a biomarker of cognitive resilience or vulnerability under changing life conditions, (3) determining whether genetic risk of AD moderates the above observed relationships.

项目总结