Data Sciences Core (Core E)

数据科学核心（核心 E）

基本信息

批准号：
10153674
负责人：
Bryan Earl Shepherd
金额：
$ 44.36万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10153674
关键词：
AIDS/HIV problem Academic Medical Centers Acquired Immunodeficiency Syndrome Address Applications Grants Area Atmosphere Award Bioinformatics Biometry Caring Cells Clinic Clinical Sciences Collaborations Communities Consult Data Data Analytics Data Collection Data Linkages Data Science Data Science Core Data Scientist Data Set Databases Development Doctor of Philosophy Feedback Fruit Funding Goals Group Meetings HIV Health Immunology Informatics Infrastructure Institution Instruction International Journals Knowledge Laboratories Leadership Link Mentorship Methods Microbiology Mission Outcome Pathology Publications Records Research Research Design Research Personnel Research Support Resources Role Science Services Site Statistical Data Interpretation Statistical Methods Strategic Planning Technology Tennessee Training Trust United States National Institutes of Health Walking Work analytical method base bioinformatics pipeline biomedical informatics computer science cost data curation data resource data sharing data tools experience genetic linkage analysis genomic data improved informatics tool investigator training medical schools member method development mid-career faculty novel professor programs success tool tool development transcriptomics working group

项目摘要

Data Sciences Core – PROJECT SUMMARY The Tennessee Center for AIDS Research (CFAR) is a four-way partnership between a research-intensive institution (Vanderbilt University Medical Center, VUMC), a historically black medical college (Meharry Medical College, MMC), an academically-engaged state health department (Tennessee Department of Health, TDH), and (newly added) a sophisticated community-based organization with an exclusive focus on HIV (Nashville CARES). Thoughtful study design, data collection, statistical analysis, and tool development are essential to high quality HIV/AIDS research. The CFAR Data Sciences Core (DSC) has been a critical component of the first cycle of the CFAR and will continue to pursue its overarching goal of elevating the quality of HIV/AIDS research. The DSC has provided statistical and informatics support to HIV/AIDS investigators at VUMC, MMC and TDH. The DSC consults with Development Core Award applicants prior to submission, provides guaranteed statistical/informatics support for award recipients, and actively collaborates with CFAR investigators at all participating institutions. The DSC collaborates closely with other cores and develops novel resources, tools, and methods to enhance HIV/AIDS research at the participating institutions and beyond. The DSC team has broad HIV research experience, including leadership roles for international HIV research consortia, long-standing collaborations with HIV investigators, experience handling and analyzing large genomic datasets, and proven track records of developing novel methods and tools informed by and beneficial to the HIV research community. The DSC will provide mentorship and training by actively participating in scientific working groups, sponsoring data science seminars, and providing topic-specific instruction at walk-in clinics. DSC services are expanding to include database development and analysis support for new partner institution, Nashville CARES, and novel bioinformatics support for CFAR investigators. The well-attended biostatistics/biomedical informatics walk-in clinics will expand from 4 clinics per month (2 at VUMC, 1 at MMC, and 1 at TDH) to 6 clinics per month by adding an additional data-focused clinic at Nashville CARES and a new bioinformatics-focused clinic at VUMC. The DC, in collaboration with the Laboratory Sciences Core, has also added expertise in high-throughput bioinformatics, so that CFAR investigators may fully take advantage of state-of-the-art single-cell transcriptomics and related technologies at Vanderbilt. DSC service offerings are continually informed by user feedback and CFAR strategic planning initiatives. The DC will support the mission of this CFAR by pursuing three specific aims: 1) Provide biostatistics, bioinformatics, and research informatics support for the CFAR.; 2) Develop databases, tools, and methods to advance HIV research in the CFAR and beyond; and 3) Provide data science training to CFAR investigators

数据科学核心 - 项目摘要田纳西州艾滋病研究中心（CFAR）是研究密集型之间的四向伙伴关系机构（VANDERBILT大学医学中心，VUMC），一所历史悠久的黑人医学院（Meharry医学院 MMC学院，学术参与的州卫生部（田纳西州卫生署，TDH），（新添加）一个基于社区的成熟组织，专注于艾滋病毒（纳什维尔）在乎）。周到的研究设计，数据收集，统计分析和工具开发对于高优质的艾滋病毒/艾滋病研究。 CFAR数据科学核心（DSC）是第一个周期的关键组成部分在CFAR中，将继续追求其提高艾滋病毒/艾滋病研究质量的总体目标。这 DSC已向VUMC，MMC和TDH的艾滋病毒/艾滋病研究人员提供了统计和信息支持。这 DSC提交之前与开发核心奖励申请的关注，提供保证授予获奖者的统计/信息学支持，并与CFAR调查人员积极合作参与机构。 DSC与其他核心紧密合作，并开发新颖的资源，工具，以及在参与机构及其他地区增强艾滋病毒/艾滋病研究的方法。 DSC团队有广泛的艾滋病毒研究经验，包括国际艾滋病毒研究财团的领导角色，长期存在与艾滋病毒研究者的合作，经验处理和分析大型基因组数据集并经过证明正在开发新方法和工具的记录，这些新方法和工具对艾滋病毒研究社区的知识和有益。 DSC将通过积极参与科学工作组来提供精神训练和培训数据科学半货人，并在步入式诊所提供特定于主题的说明。 DSC服务正在扩展到包括针对新合作伙伴机构的数据库开发和分析支持，纳什维尔关心和新颖 CFAR研究人员的生物信息学支持。受人尊敬的生物统计学/生物医学信息范围诊所将从每月4个诊所（VUMC的2个诊所，MMC的1个，TDH的1个）扩展到每月的6个诊所。在纳什维尔的护理中增加了一个以数据为重点的诊所，并在VUMC增加了一个新的以生物信息为中心的诊所。 DC与实验室科学核心合作，还增加了高通量的专业知识生物信息学，以便CFAR调查人员可以充分利用最先进的单细胞转录组学和范德比尔特的相关技术。 DSC服务产品通过用户反馈不断告知， CFAR战略规划计划。 DC将通过追求三个特定的特定目的：1）为CFAR提供生物统计学，生物信息学和研究信息。 2）发展在CFAR及其他地区推进HIV研究的数据库，工具和方法； 3）提供数据科学对CFAR调查人员的培训