Data Sciences Core (Core E)

数据科学核心（核心 E）

• 批准号: 10617309
• 负责人: Bryan Earl Shepherd
• 金额: $ 21.43万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617309
• 关键词: Academic Medical Centers; Acquired Immunodeficiency Syndrome; Address; Applications Grants; Area; Atmosphere; Award; Bioinformatics; Biometry; Cells; Clinic; Clinical Sciences; Collaborations; Communities; Consult; Data; Data Analyses; Data Analytics; Data Collection; Data Linkages; Data Science; Data Science Core; Data Scientist; Data Set; Databases; Development; Doctor of Philosophy; Feedback; Fruit; Funding; Goals; Group Meetings; HIV; HIV/AIDS; Health; Immunology; Informatics; Infrastructure; Institution; Instruction; International; Journals; Knowledge; Laboratories; Leadership; Link; Mentorship; Methods; Microbiology; Mission; Names; Outcome; Pathology; Publications; Records; Research; Research Design; Research Personnel; Research Support; Resources; Role; Rotation; Science; Services; Site; Statistical Data Interpretation; Statistical Methods; Strategic Planning; Technology; Tennessee; Training; Trust; United States National Institutes of Health; Walking; Work; analytical method; bioinformatics pipeline; biomedical informatics; community organizations; computer science; cost; data curation; data resource; data tools; experience; genomic data; improved; informatics tool; investigator training; medical schools; member; method development; mid-career faculty; novel; professor; programs; success; tool; tool development; transcriptomics; working group

Data Sciences Core – PROJECT SUMMARY The Tennessee Center for AIDS Research (CFAR) is a four-way partnership between a research-intensive institution (Vanderbilt University Medical Center, VUMC), a historically black medical college (Meharry Medical College, MMC), an academically-engaged state health department (Tennessee Department of Health, TDH), and (newly added) a sophisticated community-based organization with an exclusive focus on HIV (Nashville CARES). Thoughtful study design, data collection, statistical analysis, and tool development are essential to high quality HIV/AIDS research. The CFAR Data Sciences Core (DSC) has been a critical component of the first cycle of the CFAR and will continue to pursue its overarching goal of elevating the quality of HIV/AIDS research. The DSC has provided statistical and informatics support to HIV/AIDS investigators at VUMC, MMC and TDH. The DSC consults with Development Core Award applicants prior to submission, provides guaranteed statistical/informatics support for award recipients, and actively collaborates with CFAR investigators at all participating institutions. The DSC collaborates closely with other cores and develops novel resources, tools, and methods to enhance HIV/AIDS research at the participating institutions and beyond. The DSC team has broad HIV research experience, including leadership roles for international HIV research consortia, long-standing collaborations with HIV investigators, experience handling and analyzing large genomic datasets, and proven track records of developing novel methods and tools informed by and beneficial to the HIV research community. The DSC will provide mentorship and training by actively participating in scientific working groups, sponsoring data science seminars, and providing topic-specific instruction at walk-in clinics. DSC services are expanding to include database development and analysis support for new partner institution, Nashville CARES, and novel bioinformatics support for CFAR investigators. The well-attended biostatistics/biomedical informatics walk-in clinics will expand from 4 clinics per month (2 at VUMC, 1 at MMC, and 1 at TDH) to 6 clinics per month by adding an additional data-focused clinic at Nashville CARES and a new bioinformatics-focused clinic at VUMC. The DC, in collaboration with the Laboratory Sciences Core, has also added expertise in high-throughput bioinformatics, so that CFAR investigators may fully take advantage of state-of-the-art single-cell transcriptomics and related technologies at Vanderbilt. DSC service offerings are continually informed by user feedback and CFAR strategic planning initiatives. The DC will support the mission of this CFAR by pursuing three specific aims: 1) Provide biostatistics, bioinformatics, and research informatics support for the CFAR.; 2) Develop databases, tools, and methods to advance HIV research in the CFAR and beyond; and 3) Provide data science training to CFAR investigators

数据科学核心-项目摘要 田纳西州艾滋病研究中心（CFAR）是一个研究密集型的四方合作伙伴关系， 一个机构（范德比尔特大学医学中心，VUMC），一个历史悠久的黑人医学院（梅哈里医学院 学院，MMC），一个学术参与的州卫生部（田纳西州卫生部，TDH）， 和（新增加的）一个专门关注艾滋病毒的复杂的社区组织（纳什维尔 CARES）。深思熟虑的研究设计、数据收集、统计分析和工具开发对于高水平至关重要 高质量的艾滋病毒/艾滋病研究。CFAR数据科学核心（DSC）是第一个周期的关键组成部分 艾滋病毒/艾滋病研究中心将继续努力实现其提高艾滋病毒/艾滋病研究质量的总体目标。的 DSC向VUMC、MMC和TDH的艾滋病毒/艾滋病调查人员提供统计和信息支持。的 DSC在提交申请前咨询发展核心奖申请人， 为获奖者提供统计/信息学支持，并积极与CFAR调查人员合作 参与机构。DSC与其他核心密切合作，开发新的资源，工具， 和方法，以加强艾滋病毒/艾滋病的研究，在参与机构和超越。DSC团队已经 广泛的艾滋病毒研究经验，包括在国际艾滋病毒研究联盟中的领导作用，长期 与HIV研究人员的合作，处理和分析大型基因组数据集的经验， 开发新方法和工具的跟踪记录，这些方法和工具由艾滋病毒研究界提供信息并对艾滋病毒研究界有益。 DSC将通过积极参与科学工作组，赞助 数据科学研讨会，并在无预约诊所提供特定主题的指导。DSC服务正在扩展到 包括为新伙伴机构、纳什维尔CARES和小说提供数据库开发和分析支助 为CFAR研究人员提供生物信息学支持。生物统计学/生物医学信息学walk-in 诊所将从每月4个诊所（2个在VUMC，1个在MMC，1个在TDH）扩展到每月6个诊所， 在纳什维尔CARES增加一个额外的以数据为中心的诊所，在VUMC增加一个新的以生物信息学为中心的诊所。 DC与实验室科学核心合作，还增加了高通量方面的专业知识， 生物信息学，以便CFAR研究人员可以充分利用最先进的单细胞转录组学 和相关技术的研究DSC服务产品不断通过用户反馈获得信息， CFAR战略规划举措。DC将通过追求三个具体目标来支持该CFAR的使命 目标：1）为CFAR提供生物统计学、生物信息学和研究信息学支持。2)发展 数据库、工具和方法，以推动CFAR及其他领域的艾滋病毒研究; 3）提供数据科学 培训CFAR调查员