Data Sciences Core (Core E)

数据科学核心-项目摘要 田纳西州艾滋病研究中心(CFAR)是一个四方合作伙伴关系，由一个研究密集型 机构(Vanderbilt University Medical Center，VUMC)，历史上的黑人医学院(Meharry Medical 大学，MMC)，一个从事学术工作的州卫生局(田纳西州卫生局，TDH)， 和(新增加的)一个专门关注艾滋病毒的复杂的社区组织(纳什维尔 关心)。深思熟虑的研究设计、数据收集、统计分析和工具开发对于High 高质量的艾滋病毒/艾滋病研究。CFAR数据科学核心(DSC)一直是第一个周期的关键组成部分 中国将继续致力于提高艾滋病毒/艾滋病研究质量这一首要目标。这个 DSC向VUMC、MMC和TDH的艾滋病毒/艾滋病调查人员提供了统计和信息学支持。这个 DSC在提交前咨询发展核心奖申请者，提供保证 为获奖者提供统计/信息学支持，并积极与CFAR调查人员合作 参与机构。DSC与其他核心密切合作，开发新的资源、工具、 以及在参与机构和其他机构加强艾滋病毒/艾滋病研究的方法。DSC团队已经 广泛的艾滋病毒研究经验，包括长期担任国际艾滋病毒研究联盟的领导角色 与艾滋病毒研究人员合作，拥有处理和分析大型基因组数据集的经验，并经过验证 为艾滋病毒研究界提供信息并使其受益的开发新方法和工具的跟踪记录。 DSC将通过积极参加科学工作组、赞助 数据科学研讨会，并在无预约诊所提供特定主题的指导。DSC服务正在扩展到 包括为新伙伴机构、Nashville CARE和NOVICE提供数据库开发和分析支持 为CFAR调查人员提供生物信息学支持。出席人数众多的生物统计学/生物医学信息学研讨会 诊所数目将由每月4间(VUMC 2间、MMC 1间及TDH 1间)增加至每月6间。 在纳什维尔CARE增加了一家专注于数据的诊所，并在VUMC增加了一家专注于生物信息学的新诊所。 数据中心还与实验室科学核心合作，增加了高吞吐量方面的专业知识 生物信息学，以便CFAR调查人员可以充分利用最先进的单细胞转录组学 以及相关技术。DSC服务产品不断地由用户反馈和 CFAR战略规划倡议。区议会将通过开展三项具体工作来支持CFAR的使命 目标：1)为CFAR提供生物统计学、生物信息学和研究信息学支持；2)发展 数据库、工具和方法，以推动在CFAR和其他方面的艾滋病毒研究；以及3)提供数据科学 对CFAR调查员的培训

Data Sciences Core – PROJECT SUMMARY The Tennessee Center for AIDS Research (CFAR) is a four-way partnership between a research-intensive institution (Vanderbilt University Medical Center, VUMC), a historically black medical college (Meharry Medical College, MMC), an academically-engaged state health department (Tennessee Department of Health, TDH), and (newly added) a sophisticated community-based organization with an exclusive focus on HIV (Nashville CARES). Thoughtful study design, data collection, statistical analysis, and tool development are essential to high quality HIV/AIDS research. The CFAR Data Sciences Core (DSC) has been a critical component of the first cycle of the CFAR and will continue to pursue its overarching goal of elevating the quality of HIV/AIDS research. The DSC has provided statistical and informatics support to HIV/AIDS investigators at VUMC, MMC and TDH. The DSC consults with Development Core Award applicants prior to submission, provides guaranteed statistical/informatics support for award recipients, and actively collaborates with CFAR investigators at all participating institutions. The DSC collaborates closely with other cores and develops novel resources, tools, and methods to enhance HIV/AIDS research at the participating institutions and beyond. The DSC team has broad HIV research experience, including leadership roles for international HIV research consortia, long-standing collaborations with HIV investigators, experience handling and analyzing large genomic datasets, and proven track records of developing novel methods and tools informed by and beneficial to the HIV research community. The DSC will provide mentorship and training by actively participating in scientific working groups, sponsoring data science seminars, and providing topic-specific instruction at walk-in clinics. DSC services are expanding to include database development and analysis support for new partner institution, Nashville CARES, and novel bioinformatics support for CFAR investigators. The well-attended biostatistics/biomedical informatics walk-in clinics will expand from 4 clinics per month (2 at VUMC, 1 at MMC, and 1 at TDH) to 6 clinics per month by adding an additional data-focused clinic at Nashville CARES and a new bioinformatics-focused clinic at VUMC. The DC, in collaboration with the Laboratory Sciences Core, has also added expertise in high-throughput bioinformatics, so that CFAR investigators may fully take advantage of state-of-the-art single-cell transcriptomics and related technologies at Vanderbilt. DSC service offerings are continually informed by user feedback and CFAR strategic planning initiatives. The DC will support the mission of this CFAR by pursuing three specific aims: 1) Provide biostatistics, bioinformatics, and research informatics support for the CFAR.; 2) Develop databases, tools, and methods to advance HIV research in the CFAR and beyond; and 3) Provide data science training to CFAR investigators