Biostatistics & Biomedical Informatics Core

生物统计学

• 批准号: 8898432
• 负责人: Bryan Earl Shepherd
• 金额: $ 46.8万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8898432
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Award; Biometry; Caring; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Consultations; Data; Data Collection; Data Linkages; Data Set; Databases; Development; Distributed Databases; Doctor of Philosophy; Epidemiologist; Epidemiology; Faculty; Funding; Goals; Growth; HIV; Health; Housing; Informatics; Institution; Instruction; International; Journals; Leadership; Link; Location; Mentors; Methods; National Institute of Allergy and Infectious Disease; Output; Patients; Primary Health Care; Records; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Science; Scientist; Site; Statistical Methods; Tennessee; Time; Training; Training Support; Translational Research; Universities; Walking; biomedical informatics; cohort; experience; improved; informatics training; innovation; medical schools; novel; personalized care; population based; professor; programs; research and development; statistics; tool; tool development

Biostatistics/Biomedical Informatics – PROJECT SUMMARY Thoughtful study design, data collection, statistical analysis, and tool development are essential to high quality HIV/AIDS research. The over-arching goal of the Tennessee Center for AIDS Research (TN-CFAR) Biostatistics and Biomedical Informatics Core (BBIC) is to elevate the quality of HIV/AIDS research. The BBIC will provide statistical and biomedical informatics support to HIV/AIDS investigators at Meharry Medical College (MMC), Vanderbilt University (VU), and the Tennessee Department of Health (TDH). Specific support includes a weekly biostatistics/biomedical informatics walk-in clinic rotating its location between the 3 institutions to maximize exposure and usage, consultation for all Development Core Award applicants prior to submission and guaranteed statistics/biomedical informatics coverage for award recipients, and active collaboration with TN-CFAR investigators. We also propose to develop novel resources, tools, and methods to enhance HIV/AIDS research at the participating institutions and beyond. As a major initiative, the BBIC will link databases at TDH, create a research-ready clinical database at MMC, and harmonize these databases with existing databases at Vanderbilt that will permit integrated HIV research across the TN-CFAR. The BBIC will also develop tools for data harmonization and record counting to allow efficient real-time queries across distributed databases, and develop statistical methods that incorporate subsets of validated data into estimation. Finally, the BBIC will support training by actively participating in seminars and journal clubs, sponsoring biostatistics/biomedical informatics seminars, and providing topic- specific instruction at walk-in clinics. The BBIC team has broad HIV research experience, including leadership roles in coordinating centers for large cohorts of HIV-infected patients, extensive collaborations with HIV investigators, and proven track records of developing novel methods and tools motivated by and beneficial to HIV research.

生物统计学/生物医学信息学-项目摘要 经过深思熟虑的研究设计、数据收集、统计分析和工具开发至关重要 高质量的艾滋病毒/艾滋病研究。田纳西州艾滋病中心的总体目标 研究(TN-CFAR)生物统计和生物医学信息学核心(BBIC)旨在提升 艾滋病毒/艾滋病研究的质量。BBIC将提供统计和生物医学信息学 对范德比尔特大学梅哈里医学院(MMC)艾滋病毒/艾滋病研究人员的支持 (Vu)和田纳西州卫生部(Tdh)。具体支持包括每周一次的 生物统计/生物医学信息学无预约诊所在3个机构之间轮换位置以 最大限度地提高曝光率和使用率，咨询所有发展核心奖申请者 为获奖者提交和保证统计/生物医学信息学覆盖范围，以及 与TN-CFAR调查人员积极合作。我们还建议开发新的资源， 在参与机构和其他机构加强艾滋病毒/艾滋病研究的工具和方法。 作为一项重大举措，BBIC将连接TDH的数据库，创建一个可供研究的临床 数据库，并将这些数据库与Vanderbilt的现有数据库进行协调 将允许在TN-CFAR范围内进行综合艾滋病毒研究。BBIC还将开发工具，用于 数据协调和记录计数，允许跨分布的高效实时查询 数据库，并开发统计方法，将验证数据的子集合并到 估计。最后，BBIC将通过积极参加研讨会和 杂志俱乐部，赞助生物统计学/生物医学信息学研讨会，并提供主题- 无预约诊所的具体指导。BBIC团队拥有广泛的艾滋病毒研究经验， 包括在为大量艾滋病毒感染患者设立协调中心方面发挥领导作用， 与艾滋病毒调查人员广泛合作，并在开发新书方面有可靠的跟踪记录 由艾滋病毒研究推动并有利于艾滋病毒研究的方法和工具。