Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

研究中心摘要 该BETRNet研究中心(RC)的总体目标是： 1)对巴雷特食道(BE)进行严谨、完整的跨学科人体研究 和食管腺癌(EAC) 2)提高临床研究人员对关键观察结果的生物学理解； 3)将来自遗传、表观遗传和转录组研究的知识转化为解决临床问题 BE的发现、预后、预防和治疗的两难境地 选管会的成果； 4)培养跨学科和翻译研究文化，有效地扩大和提高科学研究 重点研究了BE和EAC； 5)评估研究和跨学科计划，并不断提高研究、生产力和 加强翻译实施。 这些目标建立在现有的多机构协作网络上并发挥协同作用，相当大的 我们机构提供的临床、基础科学和翻译专业知识，专注于改善 BE和EAC患者的预后。本中心建议书的总体组织架构为1)至 重点实验室研究，以了解遗传易感性、基因组和表观遗传学变化 影响BE和EAC的发展；2)然后将实验室发现转化为临床 应用于有效检测、分子风险分层和预防从BE到EAC的进展。

RESEARCH CENTER SUMMARY The overall objectives of this BETRNet Research Center (RC) are: 1) to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) 2) to increase the biological understanding of key observations made by our clinical researchers; 3) to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the outcomes of EAC; 4) to foster a transdisciplinary and translational research culture and to effectively expand and enhance scientific research focused on BE and EAC; 5) to evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratory discoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.