GENETIC DETERMINANTS OF BARRETT'S ESOPHAGUS AND ESOPHAGEAL ADENOCARCINOMA

巴雷特食管和食管腺癌的遗传决定因素

• 批准号: 8546709
• 负责人: AMITABH CHAK
• 金额: $ 126.84万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8546709
• 关键词: Aberrant DNA Methylation; Ablation; Accounting; Adult; Affect; Barrett Esophagus; Basic Science; Biological; Biological Markers; Center for Translational Science Activities; Cessation of life; Characteristics; Chemoprevention; Chronic; Clinical; Clinical Investigator; Collaborations; DNA; Data; Detection; Development; Diagnosis; Disease; Distant; Early Detection Research Network; Endoscopy; Epidemiologist; Epigenetic Process; Epithelium; Esophageal Adenocarcinoma; Family member; Fostering; Foundations; Gastroesophageal reflux disease; Gene Expression Profile; Genetic; Genetic Determinism; Genetic Predisposition to Disease; Genetic screening method; Genomics; Goals; Human; In Situ; Incidence; Institution; Instruction; Knowledge; Laboratories; Laboratory Scientists; Lead; Malignant Neoplasms; Methods; MicroRNAs; Modeling; Molecular; Molecular Genetics; Morbidity - disease rate; Mucous Membrane; Obesity; Outcome; Patients; Physiological; Physiology; Pilot Projects; Productivity; Public Health; Publications; Recording of previous events; Relative (related person); Research; Research Personnel; Research Project Grants; Risk; Schedule; Serological; Serum; Susceptibility Gene; Symptoms; Techniques; Testing; Therapeutic; Tissues; Translating; Translational Research; base; cancer diagnosis; cohort; deep sequencing; exome sequencing; family genetics; genetic pedigree; improved; male; meetings; mortality; outcome forecast; prevent; programs; response; screening; symposium

DESCRIPTION (provided by applicant): The overall objectives of this BETRNet Translational Research Center (TRC-F) are: 1) to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) 2) to increase the biological understanding of key observations made by our clinical researchers (familial aggregation of BE and EAC, restitution of squamous mucosa after ablation); 3) to translate knowledge derived from genetic and physiologic research to solving clinical dilemmas in detection, prognosis, and therapy of BE in order to prevent EAC and improve the outcomes of EAC;4) to foster a transdisciplinary and translational research culture and to effectively expand and enhance scientific research focused on BE and EAC; 5) to evaluate research and transdisciplinary programs and to continuously Improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this TRCF proposal is 1) to focus research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; 2) to explore the physiologic, transcriptional, and epigenetic factors that lead to durable ablation of BE; and 3) to translate discoveries into applications that improve familial screening, effective detection, molecular prognostication, and durable ablation of BE.

描述(申请人提供)：BETRNet翻译研究中心(TRC-F)的总体目标是：1)对Barrett‘s食道(BE)和食管腺癌(EAC)进行严格、完整的跨学科人类研究；2)增加我们临床研究人员对关键观察结果(BE和EAC的家族聚集，切除后鳞状黏膜的修复)的生物学理解；3)将遗传学和生理学研究的知识转化为解决BE的检测、预后和治疗的临床难题，以预防EAC并改善EAC的预后；4)培养跨学科和翻译研究文化，并有效地扩大和加强以BE和EAC为重点的科学研究；5)评估研究和跨学科计划，不断提高研究、生产率和加强翻译实施。这些目标建立在现有的多机构合作网络和我们机构提供的大量临床、基础科学和翻译专业知识的基础上，并发挥协同作用，专注于改善BE和EAC患者的预后。TRCF建议的总体组织框架是：1)重点研究影响BE和EAC发展的遗传易感性、基因组和表观遗传学变化；2)探索导致BE持久消融的生理、转录和表观遗传学因素；3)将发现转化为应用，改进BE的家系筛查、有效检测、分子预测和持久消融。