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Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

巴雷特食管和食管腺癌的遗传决定因素

基本信息

批准号：
9276253
负责人：
AMITABH CHAK
金额：
$ 135.63万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-26 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9276253
关键词：
Address African American Age Barrett Esophagus Basic Science Bibliometrics Bioinformatics Biological Biological Markers Biology Clinical Collaborations Data Coordinating Center Deposition Detection Development Devices Early Detection Research Network Epigenetic Process Esophageal Esophageal Adenocarcinoma Family Fostering Genetic Genetic Determinism Genetic Markers Genetic Predisposition to Disease Genetic Transcription Genetic screening method Genetically Engineered Mouse Genomics Goals Grant Human Institution Knowledge Laboratories Laboratory Research Laboratory Scientists Lead Legal patent Link MAPK8 gene Malignant Neoplasms Manuscripts Methods MicroRNAs Molecular Molecular Target Morbidity - disease rate NCI Center for Cancer Research Oral Pathway interactions Patient-Focused Outcomes Pilot Projects Prevention Prevention therapy Productivity Public Health Publishing RNA marker Research Research Personnel Research Project Grants Resistance Resources Risk stratification Sampling Services Statistical Methods Susceptibility Gene TGFB1 gene Techniques Testing Tissues Translating Translational Research Universities Untranslated RNA Vimentin Washington base biobank carcinogenesis clinical application epigenetic marker fusion gene improved improved outcome instructor molecular marker mortality mouse model multidisciplinary novel novel strategies outcome forecast patient registry predictive modeling prevent professor prognostic programs repository screening transcriptome transcriptomics virtual

项目摘要

RESEARCH CENTER SUMMARY The overall objectives of this BETRNet Research Center (RC) are: 1) to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) 2) to increase the biological understanding of key observations made by our clinical researchers; 3) to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the outcomes of EAC; 4) to foster a transdisciplinary and translational research culture and to effectively expand and enhance scientific research focused on BE and EAC; 5) to evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratory discoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.

研究中心总结 BETRNet研究中心（RC）的总体目标是： 1)在巴雷特食管（BE）中进行严格的、综合的跨学科人类研究食管腺癌（EAC） 2)增加我们的临床研究人员对关键观察结果的生物学理解; 3)将来自遗传学、表观遗传学和转录组研究的知识转化为解决临床 BE的检测、预后、预防和治疗中的困境，以预防EAC和改善 EAC的结果; 4)培养跨学科和转化研究文化，有效地扩大和加强科学研究，研究重点是BE和EAC; 5)评估研究和跨学科计划，并不断提高研究，生产力和加强翻译实施。这些目标建立在现有的多机构合作网络和相当大的临床，基础科学和翻译专业知识，在我们的机构，重点是提高 BE和EAC患者的结局。本驻地协调员提案的总体组织框架是：1）重点实验室研究，了解遗传易感性，基因组和表观遗传变化，影响BE和EAC的发展; 2）然后将实验室发现转化为临床用于有效检测、分子风险分层和预防BE进展为EAC。