GENETIC DETERMINANTS OF BARRETT'S ESOPHAGUS AND ESOPHAGEAL ADENOCARCINOMA

描述（申请人提供）：BETRNet翻译研究中心（TRC-F）的总体目标是：1）对巴雷特食管（BE）和食管腺癌（EAC）进行严格的、综合的跨学科人类研究2）增加我们临床研究人员对关键观察结果的生物学理解（BE和EAC的家族聚集，消融后鳞状粘膜的恢复）; 3）将遗传和生理研究中的知识转化为解决检测，预后，4）培养跨学科和转化型的研究文化，有效地扩大和加强BE和EAC的科学研究; 5）评估研究和跨学科计划，并不断提高研究，生产力和提高翻译实施。这些目标建立在现有的多机构合作网络和我们机构提供的大量临床，基础科学和转化专业知识的基础上，并发挥协同作用，重点是改善BE和EAC患者的结局。该TRCF提案的总体组织框架是：1）将研究重点放在理解影响BE和EAC发展的遗传易感性、基因组和表观遗传变化上; 2）探索导致BE持久消融的生理、转录和表观遗传因素;和3）将发现转化为应用，以改善BE的家族筛查、有效检测、分子诊断和持久消融。

DESCRIPTION (provided by applicant): The overall objectives of this BETRNet Translational Research Center (TRC-F) are: 1) to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) 2) to increase the biological understanding of key observations made by our clinical researchers (familial aggregation of BE and EAC, restitution of squamous mucosa after ablation); 3) to translate knowledge derived from genetic and physiologic research to solving clinical dilemmas in detection, prognosis, and therapy of BE in order to prevent EAC and improve the outcomes of EAC;4) to foster a transdisciplinary and translational research culture and to effectively expand and enhance scientific research focused on BE and EAC; 5) to evaluate research and transdisciplinary programs and to continuously Improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this TRCF proposal is 1) to focus research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; 2) to explore the physiologic, transcriptional, and epigenetic factors that lead to durable ablation of BE; and 3) to translate discoveries into applications that improve familial screening, effective detection, molecular prognostication, and durable ablation of BE.