Core A - Administrative Core

项目摘要--核心A：行政核心 这个行政核心(核心A)将有两个主要功能。首先，它将提供行政支持 并为本项目的研究人员提供智力丰富。由于该计划包括 来自三个机构(加州大学圣地亚哥分校、索尔克大学、科罗拉多大学)的五名高级调查人员，每个人在不同的部门， 核心A对于整合不同的管理层级至关重要。此外，还有三个不同的 脊椎动物物种将用于这项工作(人、老鼠、青蛙)，需要在动物之间移动 机构。正因为如此，并由于该方案的多学科性质，中央 行政核心是必不可少的。核心将与三个合作伙伴的管理部门密切合作 机构，以及管理人员、企业管理人员和参与其中的每个部门的科学家。这个 管理核心将：1]提供和鼓励成员之间的智力协作 计划项目、内部和外部咨询小组、不是 项目，以及外部顾问。2]协助个人私人投资主任编制预算以及协调差旅， 采购、会议和研讨会。核心将通过几种方式实现这些目标：1]我们将 支持Slack即时消息/视频门户，解决日常程序问题。2]我们每个月都有 通过视频会议为计划中的所有成员举办两个小时的研讨会。3]我们将拥有 内部咨询小组的半年度审查和外部咨询小组的两年期务虚会， 由每个PI进行演示。我们还将让核心B和C的董事提交新的数据，分析 技术和技术创新，特别是在快速发展的基因组学领域， 表观基因组学和生物信息学。研讨会平均每年10-12个，每个项目或核心 每年演讲2-3次。选择内部和外部顾问为每个项目提供建议 具体地说，将直接与他/她的PI合作，就他们的进展提出可能的新方向 对于单独的项目，以及潜在的整个计划。此外，我们建议有两个 第二年和第四年的全天研讨会，与外部咨询小组的会议重叠， 它将邀请那些在每个项目的研究方面都有相同工作的科学家。在此期间 座谈会上，每一位PI将在外部专家中介绍他们在过去两年中的进展 将被要求对每个项目的进度进行批判性评估。

PROJECT SUMMARY – Core A: Administrative Core This Administrative Core (Core A) will have two major functions. First, it will provide administrative support and intellectual enrichment for the investigators in this Program. Due to the fact that the Program includes five senior investigators from three institutions (UCSD, Salk, U Colorado), each in a different department, Core A will be essential to integrate the disparate administrative hierarchies. Additionally three different vertebrate species will be used for this work (human, mouse, frog), with the need to move animals between institutions. Because of this, and because of the multi-disciplinary nature of the Program, a central Administrative Core is essential. The Core will work closely with the administration of the three partner institutions, as well as administrators, business managers, and scientists in each department involved. The Administrative Core will: 1] Provide and encourage intellectual collaboration between members of the Program Project, Internal and External Advisory Panels, university faculty who are not members of the Project, and outside consultants. 2] Assist individual PIs in budgeting as well as coordinating travel, purchasing, meetings, and seminars. The Core will achieve these objectives in several ways: 1] We will support a Slack instant messaging/video portal for routine programmatic issues. 2] We will have monthly two-hour seminars for all Program members in this program via video conference. 3] We will have semiannual review by the Internal Advisory Group, and biennial Retreats by the External Advisory Group, with presentation by each PI. We will also have the Directors of Core B and C present new data, analytical techniques, and technological innovations, especially in the rapidly moving fields of genomics, epigenomics, and bioinformatics. Seminars will average 10-12 per year, with each Project or Core presenting 2-3 times per year. Internal and External Advisors are selected to advise each project specifically and will work directly with his/her PI regarding their progress, to suggest possible new directions for both the individual Projects, and potentially the overall Program. In addition, we propose to have two whole day symposia during Year 2 and Year 4, overlapping with the External Advisory Group meetings, in which will invite scientists whose work is on the same aspect of the research of each project. During these symposia, each of the PI’s will present their progress over the preceding two years in the outside experts will be asked to critically evaluate progress of each Project.