University of California San Diego Neuroscience Microscopy Imaging Core

加州大学圣地亚哥分校神经科学显微成像核心

• 批准号: 10524688
• 负责人: JOSEPH G GLEESON
• 金额: $ 15.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10524688
• 关键词: Administrative Supplement; Award; Books; California; Cancer Grant Supplements (P30); Center Core Grants; Communities; Consult; Core Facility; Country; Faculty; Funding; Funding Agency; Funding Mechanisms; Future; Goals; Grant; Hour; Human Resources; Imaging Device; Income; Interruption; Investments; Knowledge; Microscopy; Mission; National Institute of Neurological Disorders and Stroke; Nervous system structure; Neurosciences; Neurosciences Research; Painless; Provider; Publications; Reporting; Research; Research Personnel; Resources; Role; Services; Source; Time; United States National Institutes of Health; Universities; Vendor; base; cost; instrument; light microscopy; medical schools; microscopic imaging; nervous system disorder; operation; pandemic disease; programs; ranpirnase; repaired; success; tool

PROJECT SUMMARY / ABSTRACT The Neuroscience Microscopy Imaging Core at the UCSD School of Medicine has been fortunate to be funded continuously by the NINDS P30 program during the program’s existence from 2003 to 2021. NINDS has decided to sunset the program and this P30 grant is no longer renewable. P30 funding in the past 18 years has been instrumental in supporting the building of a world class microscopy facility that serves the microscopy imaging needs of our excellent research programs funded by NINDS, NIH, and other federal funding agencies across the entire UCSD campus. We have over 100 active user labs at any given time, with >40 labs funded by NINDS. Focusing on one type of tools in serving a large user base allows our core to operate with great efficiency. Our core is leading among the 25 or so NINDS funded P30 centers around the country in the number of supported publications. The funding of our core was considered a best value for shared facility funding in programmatic reviews. As our core transitions into a post-P30 era, we will continue to strive to meet the microscopy imaging needs of our faculty by seeking alternative funding sources, leveraging vendor relations and institutional support. We have already started to make efforts on these fronts. Nevertheless, this transition will not be painless, as resources supported by the P30 are not easily replaceable. To ease this transition and to provide a bridge to the future, we request an end-of-the-grant-cycle P30 supplement to provide a cushion so that resources previously provided by P30 will be gradually replaced by other means in the next year. This supplement will be used to support personnel, instrument repair and supplies during this transition period. We thank the NINDS for considering this supplement and for providing the P30 funding mechanisms for the past 18 years. In future, our core will continue to support the mission of the NINDS by serving a wide range of outstanding research programs that aim to gain fundamental knowledge of the nervous system and to reduce the burden of neurological diseases.

项目概要/摘要 加州大学圣地亚哥分校医学院的神经科学显微镜成像核心有幸获得资助 NINDS P30 计划在 2003 年至 2021 年期间持续由 NINDS P30 计划实施。NINDS 决定 终止该计划，并且 P30 赠款不再可更新。 P30在过去18年的资金投入 有助于支持建设服务于显微镜成像的世界一流显微镜设施 满足我们由 NINDS、NIH 和其他联邦资助机构资助的优秀研究项目的需求 整个加州大学圣地亚哥分校校园。我们在任何特定时间都有超过 100 个活跃用户实验室，其中超过 40 个实验室由 NINDS 资助。 专注于一种工具来服务庞大的用户群，使我们的核心能够高效运行。我们的 core 在全国 25 个左右 NINDS 资助的 P30 中心中，在支持数量方面处于领先地位 出版物。我们的核心资金被认为是程序化共享设施资金的最佳价值 评论。随着我们的核心过渡到后P30时代，我们将继续努力满足显微成像 通过寻求替代资金来源、利用供应商关系和机构支持来满足我们教师的需求。 我们已经开始在这些方面做出努力。然而，这种转变不会是无痛的，因为 P30支持的资源不易更换。为了简化这一过渡并为通向 未来，我们要求在拨款周期结束时提供 P30 补充，以提供缓冲，以便以前的资源 P30提供的方式将在明年逐步被其他方式取代。该补充品将用于 在此过渡期间支持人员、仪器维修和用品。我们感谢 NINDS 考虑这一补充并为过去 18 年提供 P30 融资机制。未来，我们的 core 将继续通过服务广泛的杰出研究项目来支持 NINDS 的使命 旨在获得神经系统的基础知识并减轻神经系统疾病的负担。

项目成果

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

• DOI: 10.1172/jci.insight.141344
• 发表时间: 2022-01-11
• 期刊: JCI insight
• 影响因子: 8
• 作者: Martins VF;LaBarge SA;Stanley A;Svensson K;Hung CW;Keinan O;Ciaraldi TP;Banoian D;Park JE;Ha C;Hetrick B;Meyer GA;Philp A;David LL;Henry RR;Aslan JE;Saltiel AR;McCurdy CE;Schenk S
• 通讯作者: Schenk S

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.

• DOI: 10.1371/journal.ppat.1006603
• 发表时间: 2017-09
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Guichard A;Jain P;Moayeri M;Schwartz R;Chin S;Zhu L;Cruz-Moreno B;Liu JZ;Aguilar B;Hollands A;Leppla SH;Nizet V;Bier E
• 通讯作者: Bier E

Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation.

• DOI: 10.1016/j.stem.2016.08.005
• 发表时间: 2016-11-03
• 期刊: CELL STEM CELL
• 影响因子: 23.9
• 作者: Li, Hongda;Saucedo-Cuevas, Laura;Regla-Nava, Jose A.;Chai, Guoliang;Sheets, Nicholas;Tang, William;Terskikh, Alexey V.;Shresta, Sujan;Gleeson, Joseph G.
• 通讯作者: Gleeson, Joseph G.

Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins.

• DOI: 10.1016/j.jbc.2021.100675
• 发表时间: 2021-01
• 期刊: The Journal of biological chemistry
• 作者: Liao Z;Gingras AR;Lagarrigue F;Ginsberg MH;Shattil SJ
• 通讯作者: Shattil SJ

Formation of the initial kidney and mouth opening in larval amphioxus studied with serial blockface scanning electron microscopy (SBSEM).

• DOI: 10.1186/s13227-018-0104-3
• 发表时间: 2018
• 期刊: EvoDevo
• 影响因子: 4.1
• 作者: Holland ND