University of California San Diego Neuroscience Microscopy Imaging Core

加州大学圣地亚哥分校神经科学显微成像核心

• 批准号: 10524688
• 负责人: JOSEPH G GLEESON
• 金额: $ 15.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10524688
• 关键词: Administrative Supplement; Award; Books; California; Cancer Grant Supplements (P30); Center Core Grants; Communities; Consult; Core Facility; Country; Faculty; Funding; Funding Agency; Funding Mechanisms; Future; Goals; Grant; Hour; Human Resources; Imaging Device; Income; Interruption; Investments; Knowledge; Microscopy; Mission; National Institute of Neurological Disorders and Stroke; Nervous system structure; Neurosciences; Neurosciences Research; Painless; Provider; Publications; Reporting; Research; Research Personnel; Resources; Role; Services; Source; Time; United States National Institutes of Health; Universities; Vendor; base; cost; instrument; light microscopy; medical schools; microscopic imaging; nervous system disorder; operation; pandemic disease; programs; ranpirnase; repaired; success; tool

PROJECT SUMMARY / ABSTRACT The Neuroscience Microscopy Imaging Core at the UCSD School of Medicine has been fortunate to be funded continuously by the NINDS P30 program during the program’s existence from 2003 to 2021. NINDS has decided to sunset the program and this P30 grant is no longer renewable. P30 funding in the past 18 years has been instrumental in supporting the building of a world class microscopy facility that serves the microscopy imaging needs of our excellent research programs funded by NINDS, NIH, and other federal funding agencies across the entire UCSD campus. We have over 100 active user labs at any given time, with >40 labs funded by NINDS. Focusing on one type of tools in serving a large user base allows our core to operate with great efficiency. Our core is leading among the 25 or so NINDS funded P30 centers around the country in the number of supported publications. The funding of our core was considered a best value for shared facility funding in programmatic reviews. As our core transitions into a post-P30 era, we will continue to strive to meet the microscopy imaging needs of our faculty by seeking alternative funding sources, leveraging vendor relations and institutional support. We have already started to make efforts on these fronts. Nevertheless, this transition will not be painless, as resources supported by the P30 are not easily replaceable. To ease this transition and to provide a bridge to the future, we request an end-of-the-grant-cycle P30 supplement to provide a cushion so that resources previously provided by P30 will be gradually replaced by other means in the next year. This supplement will be used to support personnel, instrument repair and supplies during this transition period. We thank the NINDS for considering this supplement and for providing the P30 funding mechanisms for the past 18 years. In future, our core will continue to support the mission of the NINDS by serving a wide range of outstanding research programs that aim to gain fundamental knowledge of the nervous system and to reduce the burden of neurological diseases.

项目总结/摘要 UCSD医学院的神经科学显微成像核心很幸运地得到了资助， NINDS P30计划在2003年至2021年期间持续进行。NINDS决定 该计划的日落和P30补助金不再是可再生的。在过去的18年里，P30的资金一直是 有助于支持世界一流的显微镜设施的建设，为显微镜成像 我们优秀的研究计划由NINDS，NIH和其他联邦资助机构资助的需求 整个UCSD校园我们在任何时候都有超过100个活跃的用户实验室，其中超过40个实验室由NINDS资助。 专注于一种类型的工具来服务于一个庞大的用户群，这使得我们的核心能够高效地运作。我们 核心是领先的25个左右的NINDS资助的P30中心在全国各地的数量支持 出版物。我们的核心资金被认为是方案中共享设施资金的最佳价值。 评论.随着我们的核心过渡到后P30时代，我们将继续努力满足显微成像 通过寻求替代资金来源，利用供应商关系和机构支持，满足我们教师的需求。 我们已开始在这方面作出努力。然而，这种过渡不会是无痛的，因为 P30支持的资源不容易替换。为了缓解这种过渡，并为 未来，我们要求在补助金周期结束时提供P30补充，以提供缓冲， P30提供的服务将在明年逐步被其他方式取代。该补充将用于 在这一过渡期间，支助人员、仪器维修和用品。我们感谢NINDS 感谢秘书长考虑这一补充，并在过去18年中提供了30个常任理事国供资机制。今后，我们的 美国国家核研究中心将继续支持国家核动力系统的使命，为范围广泛的优秀研究计划提供服务 旨在获得神经系统的基础知识，减少神经系统疾病的负担。

项目成果

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

• DOI: 10.1172/jci.insight.141344
• 发表时间: 2022-01-11
• 期刊: JCI insight
• 影响因子: 8
• 作者: Martins VF;LaBarge SA;Stanley A;Svensson K;Hung CW;Keinan O;Ciaraldi TP;Banoian D;Park JE;Ha C;Hetrick B;Meyer GA;Philp A;David LL;Henry RR;Aslan JE;Saltiel AR;McCurdy CE;Schenk S
• 通讯作者: Schenk S

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.

• DOI: 10.1371/journal.ppat.1006603
• 发表时间: 2017-09
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Guichard A;Jain P;Moayeri M;Schwartz R;Chin S;Zhu L;Cruz-Moreno B;Liu JZ;Aguilar B;Hollands A;Leppla SH;Nizet V;Bier E
• 通讯作者: Bier E

Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation.

• DOI: 10.1016/j.stem.2016.08.005
• 发表时间: 2016-11-03
• 期刊: CELL STEM CELL
• 影响因子: 23.9
• 作者: Li, Hongda;Saucedo-Cuevas, Laura;Regla-Nava, Jose A.;Chai, Guoliang;Sheets, Nicholas;Tang, William;Terskikh, Alexey V.;Shresta, Sujan;Gleeson, Joseph G.
• 通讯作者: Gleeson, Joseph G.

Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins.

• DOI: 10.1016/j.jbc.2021.100675
• 发表时间: 2021-01
• 期刊: The Journal of biological chemistry
• 作者: Liao Z;Gingras AR;Lagarrigue F;Ginsberg MH;Shattil SJ
• 通讯作者: Shattil SJ

Formation of the initial kidney and mouth opening in larval amphioxus studied with serial blockface scanning electron microscopy (SBSEM).

• DOI: 10.1186/s13227-018-0104-3
• 发表时间: 2018
• 期刊: EvoDevo
• 影响因子: 4.1
• 作者: Holland ND