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University of California San Diego Neuroscience Microscopy Imaging Core

加州大学圣地亚哥分校神经科学显微成像核心

基本信息

批准号：
10524688
负责人：
JOSEPH G GLEESON
金额：
$ 15.64万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-01 至 2022-11-30
项目状态：
已结题

项目摘要

PROJECT SUMMARY / ABSTRACT The Neuroscience Microscopy Imaging Core at the UCSD School of Medicine has been fortunate to be funded continuously by the NINDS P30 program during the program’s existence from 2003 to 2021. NINDS has decided to sunset the program and this P30 grant is no longer renewable. P30 funding in the past 18 years has been instrumental in supporting the building of a world class microscopy facility that serves the microscopy imaging needs of our excellent research programs funded by NINDS, NIH, and other federal funding agencies across the entire UCSD campus. We have over 100 active user labs at any given time, with >40 labs funded by NINDS. Focusing on one type of tools in serving a large user base allows our core to operate with great efficiency. Our core is leading among the 25 or so NINDS funded P30 centers around the country in the number of supported publications. The funding of our core was considered a best value for shared facility funding in programmatic reviews. As our core transitions into a post-P30 era, we will continue to strive to meet the microscopy imaging needs of our faculty by seeking alternative funding sources, leveraging vendor relations and institutional support. We have already started to make efforts on these fronts. Nevertheless, this transition will not be painless, as resources supported by the P30 are not easily replaceable. To ease this transition and to provide a bridge to the future, we request an end-of-the-grant-cycle P30 supplement to provide a cushion so that resources previously provided by P30 will be gradually replaced by other means in the next year. This supplement will be used to support personnel, instrument repair and supplies during this transition period. We thank the NINDS for considering this supplement and for providing the P30 funding mechanisms for the past 18 years. In future, our core will continue to support the mission of the NINDS by serving a wide range of outstanding research programs that aim to gain fundamental knowledge of the nervous system and to reduce the burden of neurological diseases.

项目摘要/摘要

项目成果

期刊论文数量（430）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.

DOI：
10.1371/journal.ppat.1006603
发表时间：
2017-09
期刊：
PLoS pathogens
影响因子：
6.7
作者：
Guichard A;Jain P;Moayeri M;Schwartz R;Chin S;Zhu L;Cruz-Moreno B;Liu JZ;Aguilar B;Hollands A;Leppla SH;Nizet V;Bier E
通讯作者：
Bier E

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

DOI：
10.1172/jci.insight.141344
发表时间：
2022-01-11
期刊：
JCI insight
影响因子：
8
作者：
Martins VF;LaBarge SA;Stanley A;Svensson K;Hung CW;Keinan O;Ciaraldi TP;Banoian D;Park JE;Ha C;Hetrick B;Meyer GA;Philp A;David LL;Henry RR;Aslan JE;Saltiel AR;McCurdy CE;Schenk S
通讯作者：
Schenk S

Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins.

DOI：
10.1016/j.jbc.2021.100675
发表时间：
2021-01
期刊：
The Journal of biological chemistry
影响因子：
0
作者：
Liao Z;Gingras AR;Lagarrigue F;Ginsberg MH;Shattil SJ
通讯作者：
Shattil SJ

Peptides displayed as high density brush polymers resist proteolysis and retain bioactivity.

肽显示为高密度刷聚合物抗蛋白水解并保留生物活性。

DOI：
10.1021/ja5088216
发表时间：
2014-10-29
期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子：
15
作者：
Blum, Angela P.;Kammeyer, Jacquelin K.;Yin, Jian;Crystal, Dustin T.;Rush, Anthony M.;Gilson, Michael K.;Gianneschi, Nathan C.
通讯作者：
Gianneschi, Nathan C.

A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila.