Interdisciplinary Bioengineering Research Training in Diabetes

项目摘要 糖尿病是一种全球性的健康流行病，影响着全球近4亿人。即使严格 糖尿病并发症的风险仍然增加。生物工程方法提供了 创新的技术，越来越多地克服目前的限制，在开发新的 糖尿病及其并发症的诊断、治疗和治愈。然而，缺乏熟练的 科学工作者能够为这些发展工作。科罗拉多大学的独特地位， 开发一个创新的新计划，以培养未来的科学家的技能和知识，以解决现有的 以及糖尿病研究和临床护理中的未来问题。这包括世界知名的研究和 糖尿病临床项目，特别是1型糖尿病;卓越的工程研究和培训 课程;和生物工程研究和培训，是完全与医学校园整合。到 保持强大的和不断增长的合作领域，交叉生物工程和糖尿病研究，我们 提出一个创新的新培训计划：糖尿病生物工程跨学科培训 Research.该计划的主要目标是：1）。为了吸引高素质的学员， 工程/定量背景; 2）.提供深入，多学科的研究培训， 整合生物工程和糖尿病的博士前培训生;和3）。为受训人员过渡到 个人奖学金和学术界或工业界的研究生涯。为了有效地实现这些目标，我们 研究培训将遵循三个核心原则：a）。一个成功的生物工程职业需要一个 本质上是多学科方法，科学家具备涵盖广泛领域的技能; B）.这些科学家的成功培训将需要学员之间的不断互动和交叉- 各级研究的学科导师; c）。培养这样的科学家需要一个机构 具有广度和深度的环境，建立了工程和临床科学之间的相互作用， 教师致力于这项培训。我们的创新研究培训计划将联合收割机教学和动手 课程作业、实验室研究、临床经验和职业技能。研究领域将集中在真正的 生物工程和糖尿病之间建立相互作用的机构的优势是 目前，包括设计生物标志物和治疗干预糖尿病和并发症，临床 试验、糖尿病和并发症的影像诊断、生物材料和基于细胞的疗法，以及 人工胰腺糖尿病管理。我们目前在生物工程培训方面取得的成果， 包括代表性不足的人群;糖尿病和工程研究方面的专业知识深度; 重要的机构支持和广泛的设施，使一个令人信服的理由， 在科罗拉多大学发展这样一个项目。

PROJECT SUMMARY Diabetes is a global heath epidemic affecting close to 400M people worldwide. Even with rigorous management increased risk for diabetic complications remains. Bioengineering approaches are providing innovate technologies that are increasingly overcoming the current limitations in developing new diagnostics, treatments and cures for diabetes and complications. However there is a shortage of a skilled scientific workforce able to work on these developments. The University of Colorado is uniquely placed to develop an innovative new program to train future scientists with the skills and knowledge to solve existing and future problems in diabetes research and clinical care. This includes world-renowned research and clinical programs in diabetes, particularly type1 diabetes; exceptional engineering research and training programs; and bioengineering research and training that is fully integrated with the Medical campus. To maintain the strong and growing areas of cooperation intersecting bioengineering and diabetes research we propose an innovative new training program: Bioengineering Interdisciplinary Training for Diabetes Research. The primary goals of this program are: 1). To attract high-quality trainees with engineering/quantitative backgrounds; 2). To provide in-depth, multi-disciplinary research training for predoctoral trainees integrating bioengineering and diabetes; and 3). To prepare trainees for transition to individual fellowships and research careers in academia or industry. To effectively achieve these goals, our research training will follow 3 core principles: a). That a successful bioengineering career requires an intrinsically multi-disciplinary approach, with scientists equipped with skills covering a broad variety of fields; b). That successful training of these scientists will require constant interactions between trainees and cross- disciplinary mentors at all levels of research; and c). That developing such scientists requires an institutional environment with breadth and depth, established interactions between engineering and clinical science, and faculty committed to this training. Our innovative research training program will combine didactic and hands on coursework, lab-based research, clinical experiences and career skills. Research areas will focus on true strengths at the institution in which established interactions between bioengineering and diabetes are present, including designing biomarkers and therapeutic interventions for diabetes and complication, clinical trials, imaging diagnostics for diabetes and complications, biomaterials and cell-based therapies, and artificial pancreas diabetes management. Our current outcomes achieved in bioengineering training, including for under-represented populations; the depth of expertise in diabetes and engineering research; the significant institutional support, and the wide range of facilities available make a compelling argument to develop such a program at the University of Colorado.