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Cell and Tissue Analysis Core

细胞和组织分析核心

基本信息

批准号：
10392980
负责人：
Richard KP Benninger
金额：
$ 18.04万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10392980
关键词：
Bioinformatics Cells Color Colorado Confocal Microscopy Custom Cytometry Data Data Analyses Data Collection Data Storage and Retrieval Device or Instrument Development Diabetes Mellitus Educational workshop Equipment Event Experimental Designs Faculty Flow Cytometry Shared Resource Fluorescence Microscopy Goals Grant Human Image Image Analysis Image Cytometry Immunology Investments Journals Lipids Maintenance Medical Metabolism Microscope Microscopy Mission Multiplexed Ion Beam Imaging Nanoscopy Preparation Productivity Reagent Research Research Personnel Resolution Resource Sharing Resources Running Sampling Series Signal Transduction Sorting - Cell Movement Specialist Speed System Teacher Professional Development Technology Tissues Training Universities Validation antibody libraries cost data handling design experimental study human imaging imaging platform innovation instrumentation intravital imaging light microscopy member microscopic imaging tool two photon microscopy two-photon

项目摘要

CELL AND TISSUE ANALYSIS CORE PROJECT SUMMARY/ABSTRACT The overall objective of the Cell and Tissue Analysis Core is to provide diabetes researchers at the University of Colorado with a unified means to access and effectively use state-of-the art microscopy and mass cytometry systems to drive innovative research. This necessarily includes providing access to this equipment; expertise and training to use the equipment effectively for diabetes-related tissues; expertise and validated diabetes- related resources to prepare samples appropriately; guidance to design experiments; resources to analyze data; and assistance with its interpretation. Fluorescence microscopy and multi-channel cytometric approaches are related tools that are central to diabetes research. The availability of higher-end systems that provide important functionalities is often limited by: 1) the high cost of the systems; 2) the costs and expertise needed to maintain these systems; 3) the specialist expertise needed to use these systems to effectively collect data; and 4) validated reagents for diabetes-related analysis. This presents a challenge for diabetes researchers to incorporate state-of-the-art microscopy and cytometry approaches in their research. The University of Colorado Anschutz Medical campus possesses state-of-the-art microscopy systems and mass-cytometry systems that have been acquired through internal investment, external shared instrumentation grants or instrument development grants. There is also tremendous expertise from expert investigators and highly trained staff. DRC support provides an opportunity to leverage these resources for diabetes researchers. The mission of this core is to provide access and enable effective usage of these sophisticated systems so that diabetes researchers can incorporate innovative approaches, to both maximize research productivity and catalyze new research directions. We will achieve these goals through the following aims: AIM 1: Enable access to state-of-the-art high-resolution multi-color confocal microscopy for diabetes researchers; AIM 2: Provide expert assistance to incorporate new advanced microscopy approaches to enhance diabetes research; AIM 3: Provide access to, and expert assistance for, state-of-the-art mass cytometry and multiplexed ion beam imaging for diabetes-related applications; AIM 4: Train diabetes researchers in incorporating new imaging and cytometry technologies in their research.

细胞和组织分析核心