Interdisciplinary Bioengineering Research Training in Diabetes

糖尿病跨学科生物工程研究培训

• 批准号: 10634690
• 负责人: Richard KP Benninger
• 金额: $ 17.77万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10634690
• 关键词: Biomedical Engineering; Diabetes Mellitus; Research Training

PROJECT SUMMARY Diabetes is a global heath epidemic affecting close to 400M people worldwide. Even with rigorous management increased risk for diabetic complications remains. Bioengineering approaches are providing innovate technologies that are increasingly overcoming the current limitations in developing new diagnostics, treatments and cures for diabetes and complications. However there is a shortage of a skilled scientific workforce able to work on these developments. The University of Colorado is uniquely placed to develop an innovative new program to train future scientists with the skills and knowledge to solve existing and future problems in diabetes research and clinical care. This includes world-renowned research and clinical programs in diabetes, particularly type1 diabetes; exceptional engineering research and training programs; and bioengineering research and training that is fully integrated with the Medical campus. To maintain the strong and growing areas of cooperation intersecting bioengineering and diabetes research we propose an innovative new training program: Bioengineering Interdisciplinary Training for Diabetes Research. The primary goals of this program are: 1). To attract high-quality trainees with engineering/quantitative backgrounds; 2). To provide in-depth, multi-disciplinary research training for predoctoral trainees integrating bioengineering and diabetes; and 3). To prepare trainees for transition to individual fellowships and research careers in academia or industry. To effectively achieve these goals, our research training will follow 3 core principles: a). That a successful bioengineering career requires an intrinsically multi-disciplinary approach, with scientists equipped with skills covering a broad variety of fields; b). That successful training of these scientists will require constant interactions between trainees and cross- disciplinary mentors at all levels of research; and c). That developing such scientists requires an institutional environment with breadth and depth, established interactions between engineering and clinical science, and faculty committed to this training. Our innovative research training program will combine didactic and hands on coursework, lab-based research, clinical experiences and career skills. Research areas will focus on true strengths at the institution in which established interactions between bioengineering and diabetes are present, including designing biomarkers and therapeutic interventions for diabetes and complication, clinical trials, imaging diagnostics for diabetes and complications, biomaterials and cell-based therapies, and artificial pancreas diabetes management. Our current outcomes achieved in bioengineering training, including for under-represented populations; the depth of expertise in diabetes and engineering research; the significant institutional support, and the wide range of facilities available make a compelling argument to develop such a program at the University of Colorado.

项目摘要 糖尿病是一种全球性荒地流行病，全球影响近40万人。即使严格 管理人员仍然增加了糖尿病并发症的风险。生物工程方法正在提供 越来越克服开发新的局限性的创新技术 诊断，治疗糖尿病和并发症的治疗方法。但是，缺乏熟练的 科学劳动力能够从事这些发展。科罗拉多大学的独特所在 制定创新的新计划，以培训未来的科学家，以解决现有的技能和知识 以及糖尿病研究和临床护理的未来问题。这包括世界知名的研究和 糖尿病的临床计划，特别是1型糖尿病；卓越的工程研究和培训 程序；以及与医疗校园完全集成的生物工程研究和培训。到 保持合作的强大而增长的领域与生物工程和糖尿病研究相交我们 提出创新的新培训计划：生物工程跨学科培训 研究。该计划的主要目标是：1）。吸引高质量的学员 工程/定量背景； 2）。提供深入的多学科研究培训 整合生物工程和糖尿病的学员；和3）。准备过渡到过渡 学术界或行业的个人奖学金和研究职业。为了有效实现这些目标，我们的 研究培训将遵循3个核心原则：A）。成功的生物工程职业需要 本质上是多学科的方法，科学家配备了涵盖各种领域的技能； b）。对这些科学家的成功培训将需要学员和跨越之间的持续互动 各个级别的研究纪律导师；和c）。发展的科学家需要机构 具有广度和深度的环境，工程与临床科学之间建立的互动，以及 致力于这项培训的教师。我们的创新研究培训计划将结合教学和双手 关于课程，基于实验室的研究，临床经验和职业技能。研究领域将集中于真实 生物工程与糖尿病之间建立互动的机构的优势是 现在，包括针对糖尿病和并发症设计生物标志物和治疗干预措施 试验，糖尿病和并发症，生物材料和基于细胞的疗法的成像诊断以及 人工胰腺糖尿病管理。我们目前在生物工程培训中取得的成果， 包括代表性不足的人群；糖尿病和工程研究的专业知识深度； 重要的机构支持以及可用的广泛设施使人有令人信服的论点 在科罗拉多大学开发这样的计划。

项目成果

Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the NOD Mouse.

混合胰岛素肽的耐受性递送可显着延长 NOD 小鼠胰岛移植物的存活时间。

• DOI: 10.2337/db20-1170
• 发表时间: 2022
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Jamison,BraxtonL;DiLisio,JamesE;Beard,KScott;Neef,Tobias;Bradley,Brenda;Goodman,Jessica;Gill,RonaldG;Miller,StephenD;Baker,RockyL;Haskins,Kathryn
• 通讯作者: Haskins,Kathryn

Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant.

• DOI: 10.3390/cells12050698
• 发表时间: 2023-02-22
• 期刊: Cells
• 影响因子: 6

Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate.

• DOI: 10.1016/j.jbc.2023.105264
• 发表时间: 2023-11
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Crawford, Samantha A;Groegler, Jason;Dang, Mylinh;Michel, Cole;Powell, Roger L;Hohenstein, Anita C;Reyes, Kaitlin;Haskins, Kathryn;Wiles, Timothy A;Delong, Thomas
• 通讯作者: Delong, Thomas

Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells.

• DOI: 10.1016/j.stemcr.2023.05.010
• 发表时间: 2023-06-13
• 期刊: STEM CELL REPORTS
• 影响因子: 5.9
• 作者: Shilleh, Ali H.;Beard, Scott;Russ, Holger A.
• 通讯作者: Russ, Holger A.