Patient Registry-Virtual Biorepository

患者登记-虚拟生物样本库

• 批准号: 10155440
• 负责人: JOEL H RUBENSTEIN
• 金额: $ 11.13万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10155440
• 关键词: Barrett Esophagus; Basic Science; Biological; Biological Process; Cell surface; Center for Translational Science Activities; Clinical; Clinical Data; Collection; DNA; Data; Disease Progression; Epidemiology; Esophageal Adenocarcinoma; Esophagus; Etiology; Formalin; Freezing; Goals; Human; Incidence; Longitudinal cohort; Malignant Neoplasms; Mucous Membrane; Neoplasms; Paraffin Embedding; Patients; Plasma; Research; Research Personnel; Research Project Grants; Serum; Specimen; Time; Update; biobank; cohort; data repository; patient registry; programs; virtual; virtual repository

Abstract – The Patient Registry-Virtual Biorepository Core will support collection of human esophageal specimens for use in the Center's translational research projects as well as for the centralized BETRNet program's virtual repository to be located at the BETRNet Coordinating Center. This Core will provide capabilities for timely sharing of specimen data with the BETRNet Coordinating Center for trans-BETRNet specimen management. This Core will provide clinical data, banked serum, plasma, somatic DNA, frozen mucosal specimens, and formalin-fixed paraffin-embedded (FFPE) mucosal specimens from a cross-sectional cohort of patients with and without BE. This Core will also provide data from a cross-sectional cohort of patients in a continuum from BE to EAC in order to facilitate identification of promising cell surface targets. This Core will also maintain, update, and provide clinical data and FFPE mucosal specimens from a longitudinal cohort of patients with BE, including those who progress to neoplasia.

摘要-患者登记处-虚拟生物库核心将支持人类食道的收集 用于中心翻译研究项目以及中央BETRNet的标本 计划的虚拟储存库将设在BETRNet协调中心。这一核心将提供 与跨BETRNet协调中心及时共享标本数据的能力 标本管理。这个核心将提供临床数据，储存的血清，血浆，体细胞DNA，冷冻 粘膜标本和福尔马林固定石蜡包埋(FFPE)粘膜标本来自横断面 BE患者和非BE患者的队列。该核心还将提供来自横截面队列的数据 患者处于从BE到EAC的连续体中，以便于识别有希望的细胞表面靶点。 该核心还将维护、更新和提供临床数据和FFPE粘膜样本 BE患者的纵向队列，包括那些进展为肿瘤的患者。