Patient Registry-Virtual Biorepository

患者登记-虚拟生物样本库

• 批准号: 10155440
• 负责人: JOEL H RUBENSTEIN
• 金额: $ 11.13万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10155440
• 关键词: Barrett Esophagus; Basic Science; Biological; Biological Process; Cell surface; Center for Translational Science Activities; Clinical; Clinical Data; Collection; DNA; Data; Disease Progression; Epidemiology; Esophageal Adenocarcinoma; Esophagus; Etiology; Formalin; Freezing; Goals; Human; Incidence; Longitudinal cohort; Malignant Neoplasms; Mucous Membrane; Neoplasms; Paraffin Embedding; Patients; Plasma; Research; Research Personnel; Research Project Grants; Serum; Specimen; Time; Update; biobank; cohort; data repository; patient registry; programs; virtual; virtual repository

Abstract – The Patient Registry-Virtual Biorepository Core will support collection of human esophageal specimens for use in the Center's translational research projects as well as for the centralized BETRNet program's virtual repository to be located at the BETRNet Coordinating Center. This Core will provide capabilities for timely sharing of specimen data with the BETRNet Coordinating Center for trans-BETRNet specimen management. This Core will provide clinical data, banked serum, plasma, somatic DNA, frozen mucosal specimens, and formalin-fixed paraffin-embedded (FFPE) mucosal specimens from a cross-sectional cohort of patients with and without BE. This Core will also provide data from a cross-sectional cohort of patients in a continuum from BE to EAC in order to facilitate identification of promising cell surface targets. This Core will also maintain, update, and provide clinical data and FFPE mucosal specimens from a longitudinal cohort of patients with BE, including those who progress to neoplasia.

摘要 - 患者登记 - 虚拟生物座核将支持人类食管的收集 用于中心的翻译研究项目以及集中式认可的标本 程序的虚拟存储库位于Betrnet协调中心。这个核心将提供 及时共享样品数据的功能 标本管理。该核心将提供临床数据，库存血清，血浆，体细胞DNA，冷冻 粘膜标本和福尔马林固定的石蜡包裹（FFPE）粘膜标本，来自横截面 有和没有BE的患者队列。该核心还将提供来自横截面队列的数据 从BE到EAC的连续体中的患者，以促进有希望的细胞表面靶标识别。 该核心还将维护，更新和提供临床数据和FFPE粘膜标本 BE患者的纵向队列，包括那些发展为肿瘤的患者。