Integrated Tomosynthetic Perfusion and Cone-beam CT Imaging on a C-arm Gantry

影像引导介入的目的是提高微创手术的疗效， 通过向医生提供基于图像的解剖和生理信息， 真实的时间。在典型的介入套件中，X射线投影图像提供图像引导。同时 通过CT/MRI套件中的灌注测量来获得生理信息。却没有一 当前的灌注成像方法可以直接在介入套间中执行。本课题 计划研究在C形臂机架上实施的新型断层合成灌注成像系统， 从所述对比动态中提取生理信息。同时提供图像引导 通过基于G臂的锥束CT，其具有使用新型扫描几何结构的上级低对比度可检测性 以及新颖的锥束图像重建算法。具体目标是：（1）实施与整合 用于C形臂机架上的断层合成成像和锥形束CT成像的数据采集方案，（2）至 校正断层合成和锥束CT扫描几何结构，（3）开发新的图像重建 断层合成灌注成像和锥形束CT成像的算法，（4）开发新的图像 断层合成灌注成像和锥形束CT成像的校正方法，以及（5）验证 断层合成灌注成像和锥形束CT成像模式， 小动物。该项目的成功完成将导致传统C形臂的升级 将系统应用于尖端的影像引导介入平台。这个平台将产生“1 +1>2” 协同效应：将获得解剖结构和生理灌注信息 使用相同的成像平台，无需将患者从手术室转移到另一个成像室 房间新平台可以在干预前、干预期间和干预后使用，以计划、指导和评估 介入手术。新的介入平台不仅有利于研究中心的人， 也将使没有先进成像的医院能够进行图像引导的介入性中风治疗 设施

The objective of image-guided intervention is to improve the efficacy of minimally invasive proceduresand reduce morbidity by providing the physician with image-based anatomical and physiological information in real time. In a typical interventional suite, X-ray projection images provide the image guidance. Meanwhile physiological information is obtained by perfusion measurements in a CT/MRI suite. However, none of the current perfusion imaging methods can be performed directly in the interventional suite. In this project,we plan to investigate a novel tomosynthetic perfusion imaging system implemented on a C-arm gantry to extract physiological information from the contrast dynamics. Meanwhile the image guidance will be provided by G-arm based cone-beam CT featuring superior low-contrast detectability using a novel scan geometry and novel cone-beam image reconstruction algorithms. The specific aims are: (1) to implement andintegrate data acquisition schemes for tomosynthetic imaging and cone-beam CT imaging on a C-arm gantry, (2) to calibrate the tomosynthetic and cone-beam CT scan geometries, (3) to develop novel imagereconstruction algorithms for tomosynthetic perfusion imaging and cone-beam CT imaging, (4) to develop novel image correction methods for tomosynthetic perfusion imaging and cone-beam CT imaging, and (5) to validate tomosynthetic perfusion imaging and cone-beam CT imaging modalities using both physical phantoms and small animals. The successful completion of this project will result in an upgrade of a conventional C-arm system to a cutting-edge image-guided interventional platform. This platform will generate "1+1 >2" synergistic effects:both anatomical structures and physiological perfusion information will be obtainable using the same imaging platform without transfering patients from an operating room to another imaging room. The new platform may be used pre-, during, and post-intervention to plan, guide, and evaluate the interventional procedures. The new interventional platform will not only benefit those at researchcenters,but also will enable image-guided interventional stroke treatmentsfor hospitals without advanced imaging facilities.