Wake Forest ADCC Administrative Supplement

项目总结 这项行政补充建议是为了资助认知电池的开发。 基于可通过电话或视频会议管理的UDSv3，并提供 初步可行性和验证数据，为未来ADRC内部验证研究提供参考。这个 拟议的补充将在阿尔茨海默病的临床核心队列中进行 位于维克森林医学院的研究中心(ADRC)，属于 ADRC的目标是提供这一队列的深入临床和认知特征。这个 该提案的基础是有证据表明，认知测试和电话管理 问卷调查是一种实用、可行的方法，已经在其他国家成功使用 学习。几种电池已经在不同的人群中验证了手机使用的有效性， 包括老年人和有轻度认知障碍和痴呆症的人。然而，a 已验证新UDSv3电池的电话版本不存在；替代方法 需要收集能够产生有效信息的ADRC数据。我们建议的补充部分将 这一努力的关键基础工作。本项目试图构建两个简短的改编 评估电池、一个核心电池和一个扩展电池，其中包括- 个人UDSv3电池，可通过电话和视频远程管理。我们计划 对来自维克森林ADRC的96名参与者进行远程评估，这些参与者 在过去六个月内进行了面对面的跟踪访问。参与者将被分配到 电话或视频管理模式，每个小组将包括先前的参与者 被判定为认知正常、MCI和痴呆症。参与者对可接受性的评分， 听力质量、疲劳感和体验的愉悦感(与他们过去对 面对面体验)将使用针对每种情况的利克特量表问卷进行评估。 还将对他们喜欢和不喜欢的东西进行定性评估。总计 管理时间、数据完整性、拒绝条件(电话或视频)或拒绝 完成每一次测试将被记录下来。参与者的认知状态(正常、MCI或痴呆)将 使用与其面对面管理相同的程序进行裁决，但裁决者 将对原有的裁决状态视而不见。我们还将审查这些协会是否 不同认知领域的测试因评估模式不同而不同。判决中的协议 也将进行探索。最后，我们将召集一个专家小组，与国家安全局和 ADRC临床工作组将制定计划，对患者进行彻底的心理测量验证 电池与其他ADRC配合使用。

PROJECT SUMMARY This administrative supplement is proposed to fund the development of a cognitive battery based on the UDSv3 that can be administered by telephone or videoconference, and to provide preliminary feasibility and validation data to inform a future inter-ADRC validation study. The proposed supplement will be conducted in the Clinical Core cohort of the Alzheimer’s Disease Research Center (ADRC) at Wake Forest School of Medicine, and falls within the scope of the ADRC’s aims to provide in-depth clinical and cognitive characterization of this cohort. The proposal is based on evidence that telephone administration of cognitive tests and questionnaires is a practical, feasible approach that has been used successfully in other studies. Several batteries have been validated for phone use in a variety of populations, including older adults and those with mild cognitive impairment and dementia. However, a validated a telephone version of the new UDSv3 battery does not exist; alternative methods of ADRC data collection that yield valid information are needed. Our proposed supplement will lay critical groundwork for this endeavor. This project seeks to construct two brief adapted assessment batteries, a Core Battery and an Expanded Battery, that include portions of the in- person UDSv3 battery that can be administered remotely by telephone and video. We plan to administer remote assessments to 96 participants from the Wake Forest ADRC who have undergone in-person follow-up visits within the past six months. Participants will be assigned to telephone or video administration modalities, and each group will include participants previously adjudicated as having normal cognition, MCI, and Dementia. Participant ratings of acceptability, hearing quality, fatigue, and pleasantness of experience (compared to their past recollection of face-to-face experience) will be assessed using Likert-scale questionnaires for each condition. Qualitative assessment of what they liked and disliked will also be conducted. Total administration time, data completeness, refusal of a condition (telephone or video), or refusal to complete each test will be recorded. Participants’ cognitive status (normal, MCI or dementia) will be adjudicated using identical procedures to their face-to-face administrations, but adjudicators will be blinded to original adjudication status. We will also examine whether the associations among tests across cognitive domains vary by assessment mode. Agreements in adjudications will also be explored. Lastly, we will convene a group of experts in consultation with the NIA and the ADRC Clinical Task Force to develop plans for thorough psychometric validation of the batteries in conjunction with other ADRCs.