T32 Translational Addiction Research Fellowship Program

T32 转化成瘾研究奖学金计划

• 批准号: 10159223
• 负责人: Julie A Blendy
• 金额: $ 48.79万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159223
• 关键词: Fellowship Program; Research; addiction

Addictions and the associated public health problems of HIV transmission, crime and violence, exact a severe toll on our nation, costing billions annually in health care, lost productivity, and incarceration. As there have been rapid advances in neuroscience and genetics in the past two decades, we need to speed the "forward" translation of this knowledge into more effective clinical treatments for the addictions. Conversely, for addiction treatments with some known efficacy, we can now apply new neuroscience and genetic tools in "backward- translation" -- e.g., finding why a treatment works well for some individuals, yet not at all for others. To help meet the need for skilled translational researchers, this application proposes continuation of a successful (17 total trainees; 13 in the current funding period) NIDA T32 Translational Addiction Research Fellowship at the University of Pennsylvania. The (pre- and postdoctoral) training program make explicit a long-standing translational tradition at Penn, integrating clinical and basic research strengths to create trainees, whether clinical or preclinical, Ph.D.s or M.D.s, who will accelerate addiction science in the next decade. The emphasis on translation is reflected at each level of the program - through the Co-PIs (clinical and basic, Drs. Childress and Pierce), the internal and external advisory board members, the formal didactics, the "dual" (clinical - preclinical) mentoring, and in the trainees' mentored research projects. The translational emphasis of the program is driven by the recognition that addictions are complex disorders, multi-determined by interaction of genetic vulnerabilities, exposure to drug, and a host of modulating (e.g., early trauma ,stress, cultural norms) influences. Trainees are thus offered state-of-the-art knowledge about these interacting determinants through a didactic series specific to the program, and through mentored projects that may range from molecular and genetic studies, to brain systems (neuroscience and neuroimaging), to clinical treatment trials, and drug policy. This wide range of choices is enabled by the long history of excellence in addiction research at the University, reflected in the several academic research Centers (Penn Center for Studies on Addiction; Translational Research Laboratories/CNB; Center for AIDS Research; Center for Integrated Nicotine Research (CIRNA), the Treatment Research Institute, and collaborative laboratories offering skilled, successful mentors to the Fellowship. Mentored research also takes place within several affiliated treatment settings (VA, Presby-Penn, community methadone clinics, and mobile HIV Prevention units), critical for translating new research findings into the "real world”.

成瘾以及艾滋病毒传播，犯罪和暴力的相关公共卫生问题，正是严重的 对我们国家的损失，每年在医疗保健中损失数十亿美元，生产力失去和监禁。如有 在过去的二十年中，我们在神经科学和遗传学方面取得了迅速的进步，我们需要加快“前进”的速度 将这种知识转化为成瘾的更有效的临床治疗方法。相反，成瘾 以某些已知效率的治疗，我们现在可以在“向后”中应用新的神经科学和遗传工具 翻译” - 例如，找出为什么一种治疗对某些人效果很好，但对其他人来说根本没有。 满足对熟练翻译研究人员的需求，这项申请提案继续成功（17 总学员； 13在当前的资助期）NIDA T32翻译成瘾研究研究金 宾夕法尼亚大学。 （前和博士后）培训计划使显式成为长期存在的 宾夕法尼亚州的翻译传统，整合临床和基础研究的优势以创造受训者，是否 临床或临床前博士或M.D.S博士，他们将在未来十年加速成瘾科学。重点 在程序的每个级别上，翻译都反映了 - 通过共同案件（临床和基本，childress博士 和Pierce），内部和外部顾问委员会成员，正式教学法，“双重”（临床 - 临床前的心理，以及学员的精神研究项目。翻译的重点 计划的驱动是由认识到成瘾是复杂的疾病，多确定的。 遗传脆弱性，暴露于药物和许多调节（例如早期创伤，压力，文化规范） 影响。因此，通过 特定于该程序的教学级数，以及通过分子和可能范围从分子和 遗传研究，脑系统（神经科学和神经影像学），临床治疗试验和药物政策。 这种广泛的选择是由大学成瘾研究的悠久历史所促进的， 反映在几个学术研究中心（宾夕法尼亚成瘾研究中心；翻译 研究实验室/CNB；艾滋病研究中心；尼古丁综合研究中心（CIRNA）， 治疗研究所和合作实验室，为熟练的导师提供熟练的导师 奖学金。指导研究也发生在几个会员治疗环境中（VA，Persby-Penn， 社区MEDAGADONE诊所和移动艾滋病毒预防单位），对于翻译新研究结果至关重要 进入“现实世界”。