Engagement in Longevity and Medicine (ELM)

项目概要/摘要 该项目的目标是建立一个集中的研究基础设施，利用纽约大学 (NYU)Langone Health在整个纽约市的临床和社区合作伙伴关系， 推进社区参与科学，招募和保留老龄化和阿尔茨海默氏症及相关 痴呆症（ADRD）研究。尽管老年人和老年人口增长迅速， 在少数种族和族裔中，这些人在临床研究中的代表性不足。年龄较大 参与者在参与、招聘和留住人才方面面临着与年轻人不同的挑战 在人类研究中。这些问题包括对慢性病复杂性、行动能力限制、 以及可能限制获得研究机会或同意能力的认知和感官障碍。 因此，在医疗保健干预中起作用的证据不太适用于老年人群， 特别是对少数群体和低收入社区而言，尽管认识到 这些社区之间的健康差距。 为了解决这些问题，纽约大学参与长寿和医学（ELM）研究合作将 评价和传播在吸引、征聘和留住老年人方面的最佳做法， 制定和测试社区参与和以技术为基础的创新办法， 在临床和社区环境中进行招聘，并加强量身定制的沟通和信息战略 多样化的老龄化研究人群，包括ADRD社区和代表国家 老龄化研究所的优先人群。 为了增加老年受试者对老龄化和ADRD研究的参与、招募和保留， 纽约大学ELM研究合作将：1）建立一个集中的基础设施，包括社区成员， 临床研究人员，以及老龄化和ADRD研究中的患者和家庭利益相关者; 2）分析和评估 在招聘和留住人才方面，目前已知的成功战略和挑战是什么; 3）制定 使用电子健康记录系统和社区进行教育和参与的创新方法 植根于社区卫生工作者模式的导航员; 4）建立和部署一个新颖的培训计划， 研究团队使用模拟与演员作为潜在的主题;和5）开发一个基础广泛的研究 反映美国老年人群多样性的潜在受试者登记研究。本研究将 为正在进行的老龄化和ADRD临床试验提供直接益处，并为未来的试验提供实质性支持。

PROJECT SUMMARY/ABSTRACT The goal of this project is to establish a centralized research infrastructure that harnesses New York University (NYU) Langone Health’s clinical and community partnerships throughout New York City to strengthen and advance the science of community engagement, recruitment and retention in aging and Alzheimer’s and related dementia (ADRD) research. Despite the tremendous growth in the older adult and elderly population, particularly among racial and ethnic minorities, these individuals are underrepresented in clinical research. Older age participants face challenges that differ from younger age populations in engagement, recruitment and retention in human subjects research. These include concerns about chronic disease complexities, mobility limitations, and cognitive and sensory impairments that may limit access to research opportunities or capacity to consent. As a result, the evidence of what works in healthcare interventions is less generalizable to older populations, particularly for minority and low-income communities despite the recognition of the disproportionate burden of health disparities among these communities. To address these concerns, the NYU Engagement in Longevity and Medicine (ELM) Research Collaborative will evaluate and disseminate best practices in engaging, recruiting and retaining older populations, stimulate the development and testing of innovative community-engaged and technology-based approaches to participant recruitment in clinical and community settings, and strengthen communication and messaging strategies tailored to diverse aging research populations that are inclusive of ADRD communities and representative of the National Institute on Aging’s priority populations. To increase engagement, recruitment, and retention of older age subjects into aging and ADRD research, the NYU ELM Research Collaborative will: 1) establish a centralized infrastructure including community members, clinical researchers, and patient and family stakeholders in aging and ADRD research; 2) analyze and evaluate what is currently known about successful strategies and challenges in recruitment and retention; 3) develop innovative approaches for education and engagement using electronic health record systems and community navigators rooted in the community health worker model; 4) build and deploy a novel training program for research teams using simulation with actors as potential subjects; and 5) develop a broad-based research registry of interested potential subjects reflective of the diversity of the older adult US population. This study will provide immediate benefit to ongoing aging and ADRD clinical trials and substantial support to future trials.