Engagement in Longevity and Medicine (ELM)

项目摘要/摘要 该项目的目标是建立一个集中的研究基础设施，利用纽约大学 (纽约大学)朗格尼健康公司在纽约市的临床和社区合作伙伴关系，以加强和 促进老龄化和阿尔茨海默氏症及相关的社区参与、招募和保留的科学 痴呆症(ADRD)研究。尽管老年人和老年人口大幅增长，特别是 在种族和少数民族中，这些人在临床研究中的代表性不足。高龄 参与者在参与度、招聘和留住方面面临着与年轻人群不同的挑战 在人类受试者研究中。这些问题包括对慢性病复杂性、行动不便、 以及认知和感觉障碍，可能会限制获得研究机会或同意的能力。 因此，医疗干预措施奏效的证据不太适用于老年人口， 特别是对于少数群体和低收入社区，尽管人们认识到 这些社区之间的健康差距。 为了解决这些担忧，纽约大学参与长寿与医学(ELM)研究合作将 评估和传播在吸引、招募和留住老年人口方面的最佳做法，鼓励 为参与者开发和测试创新的社区参与和基于技术的方法 在临床和社区环境中进行招聘，并加强为其量身定做的沟通和信息策略 面向包括ADRD社区在内的不同老龄化研究人群，并代表国家 老龄化优先人口研究所。 为了增加老年受试者对老龄化和ADRD研究的参与度、招募和留存， 纽约大学榆树研究协作组将：1)建立包括社区成员在内的中央基础设施， 老龄化和ADRD研究中的临床研究人员、患者和家庭利益相关者；2)分析和评估 目前在招聘和留住方面的成功战略和挑战是什么；3)发展 使用电子健康记录系统和社区进行教育和参与的创新方法 扎根于社区卫生工作者模式的领航员；4)建立和部署新的培训计划，以 使用模拟演员作为潜在研究对象的研究团队；以及5)开发基础广泛的研究 登记感兴趣的潜在受试者，反映美国老年人口的多样性。这项研究将 为正在进行的老龄化和ADRD临床试验提供立竿见影的好处，并为未来的试验提供实质性支持。

PROJECT SUMMARY/ABSTRACT The goal of this project is to establish a centralized research infrastructure that harnesses New York University (NYU) Langone Health’s clinical and community partnerships throughout New York City to strengthen and advance the science of community engagement, recruitment and retention in aging and Alzheimer’s and related dementia (ADRD) research. Despite the tremendous growth in the older adult and elderly population, particularly among racial and ethnic minorities, these individuals are underrepresented in clinical research. Older age participants face challenges that differ from younger age populations in engagement, recruitment and retention in human subjects research. These include concerns about chronic disease complexities, mobility limitations, and cognitive and sensory impairments that may limit access to research opportunities or capacity to consent. As a result, the evidence of what works in healthcare interventions is less generalizable to older populations, particularly for minority and low-income communities despite the recognition of the disproportionate burden of health disparities among these communities. To address these concerns, the NYU Engagement in Longevity and Medicine (ELM) Research Collaborative will evaluate and disseminate best practices in engaging, recruiting and retaining older populations, stimulate the development and testing of innovative community-engaged and technology-based approaches to participant recruitment in clinical and community settings, and strengthen communication and messaging strategies tailored to diverse aging research populations that are inclusive of ADRD communities and representative of the National Institute on Aging’s priority populations. To increase engagement, recruitment, and retention of older age subjects into aging and ADRD research, the NYU ELM Research Collaborative will: 1) establish a centralized infrastructure including community members, clinical researchers, and patient and family stakeholders in aging and ADRD research; 2) analyze and evaluate what is currently known about successful strategies and challenges in recruitment and retention; 3) develop innovative approaches for education and engagement using electronic health record systems and community navigators rooted in the community health worker model; 4) build and deploy a novel training program for research teams using simulation with actors as potential subjects; and 5) develop a broad-based research registry of interested potential subjects reflective of the diversity of the older adult US population. This study will provide immediate benefit to ongoing aging and ADRD clinical trials and substantial support to future trials.