Genetic and Environmental Risk for Alcohol and Eating Disorders Across Development

整个发育过程中酒精和饮食失调的遗传和环境风险

• 批准号: 10164691
• 负责人: Melissa Anne Munn-Chernoff
• 金额: $ 15.46万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-05 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10164691
• 关键词: Address; Adolescence; Adolescent; Adolescent Development; Adult; Affect; Age; Alcohol Phenotype; Alcohol consumption; Alcohols; Anorexia Nervosa; Behavior; Binge eating disorder; Biological; Bulimia; Cessation of life; Child; Clinical; Data; Development; Diagnosis; Disease; Early Diagnosis; Eating Disorders; Emotional; Environment; Environmental Risk Factor; Epidemiologist; Etiology; Exposure to; Family; Funding; Future; Genetic; Genetic Predisposition to Disease; Genetic Risk; Genomics; Goals; Heritability; Individual; Institution; Instruction; International; Intervention; Measures; Mentors; Mentorship; Methodology; Methods; Modernization; Nature; North Carolina; Pathology; Patients; Pattern; Personal Satisfaction; Phenotype; Prevalence; Prevention; Prevention strategy; Procedures; Protocols documentation; Psychiatry; Psychologist; Recording of previous events; Research; Research Design; Research Project Grants; Research Training; Risk; Sampling; Severities; Specialist; Substance Use Disorder; Sum; Sweden; Symptoms; Time; Training; Twin Multiple Birth; Twin Studies; United States National Institutes of Health; Universities; Validation; Washington; Woman; Work; age group; alcohol comorbidity; alcohol involvement; alcohol measurement; alcohol risk; alcohol use disorder; career; childhood adversity; clinical practice; comorbidity; disability; disorder risk; experience; genetic association; genetic risk factor; genome wide association study; genomic locus; high risk; indexing; mortality; novel; polygenic risk score; professor; programs; psychiatric genomics; public health relevance; risk variant; societal costs; substance use; working group; young adult

PROJECT SUMMARY Candidate: I am an Assistant Professor in the Department of Psychiatry at the University of North Carolina at Chapel Hill (UNC-CH). My overarching career goal is to develop an independent NIH-funded program of research that explicates the etiology of comorbid alcohol involvement (AI) and eating disorder (ED) pathology using sophisticated and comprehensive statistical methodologies that incorporate both genetic and environmental risk. I seek additional instruction in: (1) advanced training in ED and alcohol phenotypes; (2) adolescent development; and (3) modern genomic analyses. Research Project: Existing data from the Child and Adolescent Twin Study in Sweden (CATSS) will be leveraged with existing genome-wide association study (GWAS) data from the Psychiatric Genomics Consortium (PGC) to explore the manner and extent to which the comorbidity between AI and ED pathology are accounted for by genetic and environmental factors. Specific aims are to: (1) obtain descriptive information and explore genetic and environmental effects on comorbid AI and ED pathology in adolescence and young adulthood, and investigate the extent to which childhood adversity affects this association; (2) identify shared genetic risk factors for AI and ED pathology; and (3) develop and apply polygenic risk scores for AI and ED pathology to more comprehensively examine the genetic etiology of these behaviors. This research will provide crucial information to explicate the comorbidity between AI and ED pathology, as well as ultimately assist in developing targeted prevention strategies and enhance early detection and tailored interventions for these debilitating behaviors. Environment: The research and training will occur primarily at UNC-CH and secondarily at Washington University in St. Louis, MO (Department of Psychiatry). Training at both institutions is essential in order to work with the statisticians who are at the forefront of applying the methods proposed here to both AI and ED pathology. Mentors and Collaborators/Consultants: The mentorship team includes primary mentor, Dr. Cynthia Bulik, a clinical adolescent psychologist, internationally recognized ED specialist, and co-chair of the PGC-Eating Disorders working group; and co-mentor, Dr. Arpana Agrawal, a genetic and psychiatric epidemiologist, internationally recognized alcohol and substance use specialist, and co-chair of the PGC-Substance Use Disorders working group. Collaborators/consultants are: Dr. Andrea Hussong (developmental psychologist specializing in substance use and developmental trajectories); Dr. Paul Lichtenstein (genetic epidemiologist and CATSS PI); Dr. Kari North (genetic epidemiologist specializing in GWAS); and Dr. Benjamin Neale (statistical geneticist specializing in novel genomic analyses).

项目摘要 候选人：我是北卡罗来纳州大学精神病学系的助理教授， 查佩尔山（UNC-CH）。我的首要职业目标是开发一个独立的NIH资助的项目， 阐明酒精参与（AI）和进食障碍（艾德）病理学共病病因的研究 使用复杂和全面的统计方法， 环境风险。我寻求额外的指导：（1）在艾德和酒精表型的高级培训;（2） 青少年发育;（3）现代基因组分析。研究项目：来自儿童的现有数据 瑞典青少年双胞胎研究（CATSS）将与现有的全基因组关联研究相结合 （GWAS）的数据，以探索精神病基因组学联盟（PGC）的方式和程度， AI和艾德病理学之间的共病由遗传和环境因素解释。具体 目的是：（1）获得描述性信息，探索遗传和环境对共病AI的影响 和艾德病理在青春期和年轻的成年，并调查在多大程度上， 逆境影响这种关联;（2）确定AI和艾德病理学共有的遗传风险因素;（3） 开发和应用AI和艾德病理学的多基因风险评分，以更全面地检查 这些行为的遗传病因。这项研究将为解释这一共同现象提供重要信息 AI和艾德病理学之间的关系，并最终帮助制定有针对性的预防策略， 加强对这些使人衰弱的行为的早期发现和有针对性的干预。环境：研究 培训将主要在联合国大学芝加哥分校进行，其次在密苏里州圣路易斯市的华盛顿大学进行 （精神科）。在这两个机构进行培训是必不可少的，以便与 在将本文提出的方法应用于AI和艾德病理学方面处于最前沿。导师和 合作者/顾问：导师团队包括主要导师Cynthia Bulik博士，一位临床 青少年心理学家，国际公认的艾德专家，PGC饮食失调联合主席 工作组;共同导师，遗传和精神病流行病学家Arpana Agrawal博士，国际 公认的酒精和物质使用专家，以及PGC物质使用障碍的联合主席， 组合作者/顾问是：Andrea Hussong博士（发展心理学家，专门从事 Dr. Paul Lichelman（遗传流行病学家和CATSS PI）; 博士Kari North（专门研究GWAS的遗传流行病学家）和Benjamin Neale博士（统计遗传学家 专门从事新的基因组分析）。

项目成果

Premenstrual symptoms as a marker of ovarian hormone sensitivity in eating disorders.

• DOI: 10.1002/eat.23213
• 发表时间: 2020-02
• 期刊: The International journal of eating disorders
• 作者: Hardin SL;Thornton LM;Munn-Chernoff MA;Baker JH
• 通讯作者: Baker JH

Food-restricted alcohol consumption: relation to psychopathology in college students.

• DOI: 10.1080/07448481.2021.1891915
• 发表时间: 2023-03
• 期刊: Journal of American college health : J of ACH
• 作者: Qi B;Humphrey A;Bulik CM;Baker JH;Munn-Chernoff MA
• 通讯作者: Munn-Chernoff MA

The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods.

神经性厌食症遗传学倡议 (ANGI)：概述和方法。

• DOI: 10.1016/j.cct.2018.09.015
• 发表时间: 2018
• 期刊: Contemporary clinical trials
• 影响因子: 2.2
• 作者: Thornton,LauraM;Munn-Chernoff,MelissaA;Baker,JessicaH;Juréus,Anders;Parker,Richard;Henders,AnjaliK;Larsen,JanneT;Petersen,Liselotte;Watson,HunnaJ;Yilmaz,Zeynep;Kirk,KatherineM;Gordon,Scott;Leppä,VirpiM;Martin,FelicityC

Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains.

• DOI: 10.3390/ijms22115443
• 发表时间: 2021-05-21
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Jimenez Chavez CL;Bryant CD;Munn-Chernoff MA;Szumlinski KK
• 通讯作者: Szumlinski KK

Illicit Drug Use, Cigarette Smoking, and Eating Disorder Symptoms: Associations in an Adolescent Twin Sample.

非法药物使用、吸烟和饮食失调症状：青少年双胞胎样本中的关联。

• DOI: 10.15288/jsad.2018.79.720
• 发表时间: 2018
• 期刊: Journal of studies on alcohol and drugs
• 影响因子: 3.4
• 作者: Baker,JessicaH;Johnson,NicoleK;Munn-Chernoff,MelissaA;Lichtenstein,Paul;Larsson,Henrik;Maes,HermineH;Kendler,KennethS
• 通讯作者: Kendler,KennethS