Genetic and Environmental Risk for Alcohol and Eating Disorders Across Development

项目总结

PROJECT SUMMARY Candidate: I am an Assistant Professor in the Department of Psychiatry at the University of North Carolina at Chapel Hill (UNC-CH). My overarching career goal is to develop an independent NIH-funded program of research that explicates the etiology of comorbid alcohol involvement (AI) and eating disorder (ED) pathology using sophisticated and comprehensive statistical methodologies that incorporate both genetic and environmental risk. I seek additional instruction in: (1) advanced training in ED and alcohol phenotypes; (2) adolescent development; and (3) modern genomic analyses. Research Project: Existing data from the Child and Adolescent Twin Study in Sweden (CATSS) will be leveraged with existing genome-wide association study (GWAS) data from the Psychiatric Genomics Consortium (PGC) to explore the manner and extent to which the comorbidity between AI and ED pathology are accounted for by genetic and environmental factors. Specific aims are to: (1) obtain descriptive information and explore genetic and environmental effects on comorbid AI and ED pathology in adolescence and young adulthood, and investigate the extent to which childhood adversity affects this association; (2) identify shared genetic risk factors for AI and ED pathology; and (3) develop and apply polygenic risk scores for AI and ED pathology to more comprehensively examine the genetic etiology of these behaviors. This research will provide crucial information to explicate the comorbidity between AI and ED pathology, as well as ultimately assist in developing targeted prevention strategies and enhance early detection and tailored interventions for these debilitating behaviors. Environment: The research and training will occur primarily at UNC-CH and secondarily at Washington University in St. Louis, MO (Department of Psychiatry). Training at both institutions is essential in order to work with the statisticians who are at the forefront of applying the methods proposed here to both AI and ED pathology. Mentors and Collaborators/Consultants: The mentorship team includes primary mentor, Dr. Cynthia Bulik, a clinical adolescent psychologist, internationally recognized ED specialist, and co-chair of the PGC-Eating Disorders working group; and co-mentor, Dr. Arpana Agrawal, a genetic and psychiatric epidemiologist, internationally recognized alcohol and substance use specialist, and co-chair of the PGC-Substance Use Disorders working group. Collaborators/consultants are: Dr. Andrea Hussong (developmental psychologist specializing in substance use and developmental trajectories); Dr. Paul Lichtenstein (genetic epidemiologist and CATSS PI); Dr. Kari North (genetic epidemiologist specializing in GWAS); and Dr. Benjamin Neale (statistical geneticist specializing in novel genomic analyses).