Genetic and Environmental Risk for Alcohol and Eating Disorders Across Development

项目总结 候选人：我是北卡罗来纳大学精神病学系的助理教授 教堂山(北卡罗来纳州-CH)。我的首要职业目标是开发一个由NIH资助的独立项目 解释酒精参与(AI)和进食障碍(ED)共病病理病因的研究 使用复杂和全面的统计方法，包括遗传和 环境风险。我寻求更多的指导：(1)ED和酒精表型的高级培训；(2) 青少年发育；以及(3)现代基因组分析。研究项目：来自儿童的现有数据 瑞典青少年双胞胎研究(CATSS)将与现有的全基因组关联研究相结合 来自精神病学基因组学联盟(PGC)的数据，以探索 AI和ED病理之间的共病是由遗传和环境因素引起的。特定的 目的是：(1)获得描述性信息，并探索遗传和环境对共生人工智能的影响 以及青春期和青春期的ED病理，并调查儿童 逆境影响这种联系；(2)确定AI和ED病理的共同遗传风险因素；以及(3) 开发和应用AI和ED病理学的多基因风险评分，以更全面地检查 这些行为的遗传病因学。这项研究将为解释共病提供关键信息。 人工智能和ED病理学之间的联系，以及最终协助制定有针对性的预防战略和 加强对这些令人衰弱的行为的早期发现和量身定做的干预。环境：研究 培训将主要在北卡罗来纳大学进行，其次是密苏里州圣路易斯市的华盛顿大学 (精神病学系)在这两个机构进行培训是必不可少的，以便与统计人员合作 处于将这里提出的方法应用于人工智能和ED病理学的前沿。导师和 合作者/顾问：导师团队包括主要导师、临床医生Cynthia Bulik 青少年心理学家，国际公认的ED专家，PGC-饮食障碍联席主席 工作组；国际遗传和精神流行病学家Arpana Agrawal博士的共同导师 公认的酒精和物质使用专家，以及PGC-物质使用障碍工作的联合主席 一群人。合作者/顾问是：Andrea HusSong博士(专门研究 物质使用和发育轨迹)；保罗·利希滕斯坦博士(遗传流行病学家和CATSS Pi)； Kari North博士(专门研究GWAS的遗传流行病学家)和Benjamin Neale博士(统计遗传学家 专门从事新的基因组分析)。

PROJECT SUMMARY Candidate: I am an Assistant Professor in the Department of Psychiatry at the University of North Carolina at Chapel Hill (UNC-CH). My overarching career goal is to develop an independent NIH-funded program of research that explicates the etiology of comorbid alcohol involvement (AI) and eating disorder (ED) pathology using sophisticated and comprehensive statistical methodologies that incorporate both genetic and environmental risk. I seek additional instruction in: (1) advanced training in ED and alcohol phenotypes; (2) adolescent development; and (3) modern genomic analyses. Research Project: Existing data from the Child and Adolescent Twin Study in Sweden (CATSS) will be leveraged with existing genome-wide association study (GWAS) data from the Psychiatric Genomics Consortium (PGC) to explore the manner and extent to which the comorbidity between AI and ED pathology are accounted for by genetic and environmental factors. Specific aims are to: (1) obtain descriptive information and explore genetic and environmental effects on comorbid AI and ED pathology in adolescence and young adulthood, and investigate the extent to which childhood adversity affects this association; (2) identify shared genetic risk factors for AI and ED pathology; and (3) develop and apply polygenic risk scores for AI and ED pathology to more comprehensively examine the genetic etiology of these behaviors. This research will provide crucial information to explicate the comorbidity between AI and ED pathology, as well as ultimately assist in developing targeted prevention strategies and enhance early detection and tailored interventions for these debilitating behaviors. Environment: The research and training will occur primarily at UNC-CH and secondarily at Washington University in St. Louis, MO (Department of Psychiatry). Training at both institutions is essential in order to work with the statisticians who are at the forefront of applying the methods proposed here to both AI and ED pathology. Mentors and Collaborators/Consultants: The mentorship team includes primary mentor, Dr. Cynthia Bulik, a clinical adolescent psychologist, internationally recognized ED specialist, and co-chair of the PGC-Eating Disorders working group; and co-mentor, Dr. Arpana Agrawal, a genetic and psychiatric epidemiologist, internationally recognized alcohol and substance use specialist, and co-chair of the PGC-Substance Use Disorders working group. Collaborators/consultants are: Dr. Andrea Hussong (developmental psychologist specializing in substance use and developmental trajectories); Dr. Paul Lichtenstein (genetic epidemiologist and CATSS PI); Dr. Kari North (genetic epidemiologist specializing in GWAS); and Dr. Benjamin Neale (statistical geneticist specializing in novel genomic analyses).