Research Methods Core

研究方法核心

• 批准号: 10172081
• 负责人: Clemma Jacobsen Muller
• 金额: $ 31.07万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10172081
• 关键词: Aging; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American Indians; Behavior Therapy; Biometry; Chippewa; Clinical; Clinical Trials; Clinical Trials Cooperative Group; Collaborations; Communities; Community Health; Data; Data Analytics; Data Collection; Diagnosis; Disease; Ensure; Epidemiologist; Epidemiology; Ethnic group; Evaluation; Faculty; Funding; Goals; Grant; Health; Health Personnel; Health Services Research; Health Status; Health behavior; Healthcare; Healthy People 2020; High Prevalence; Hypertension; Indigenous; Individual; Infrastructure; Intervention Studies; Intervention Trial; Lead; Life Expectancy; Life Style; Logistics; Measurable; Measurement; Measures; Medicine; Methodology; Methods; Minnesota; Minority; Native Hawaiian; Native-Born; Non-Insulin-Dependent Diabetes Mellitus; Pacific Island Americans; Physical activity; Play; Policies; Population; Prevalence; Prevention; Public Health; Qualitative Research; Race; Reproducibility; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Resource Allocation; Resources; Risk; Role; Sample Size; Sampling; Science; Sleep Disorders; Smoking; Standardization; Statistical Data Interpretation; Training; Trust; United States National Institutes of Health; Universities; Validity and Reliability; Washington; Work; base; college; community setting; database design; design; evidence base; experience; flexibility; genetic epidemiology; health disparity; health inequalities; improved; innovation; instrument; low socioeconomic status; member; mid-career faculty; mild cognitive impairment; professor; racial and ethnic disparities; randomized trial; skills; social

RESEARCH METHODS CORE: ABSTRACT Healthy People 2020 calls for research and policy to eliminate racial and ethnic disparities in health status, health behaviors, functional limitations, and healthcare use. Although progress has been made toward these goals, large disparities persist for American Indians, Alaska Natives, Native Hawaiians, and Pacific Islanders. These groups have a high prevalence of risk factors for Alzheimer’s disease and related dementias and are at greater risk than other groups for under diagnosis of these disorders. Accordingly, the Natives Engaged in Alzheimer’s Research Center will conduct community-based Alzheimer’s disease and related dementias studies within American Indian, Alaska Native, Native Hawaiian, and Pacific Islander populations using methods and instruments that yield accurate, reliable data. The Research Methods Core’s primary function is to collaborate with individual Research Projects and Cores, sharing expertise to improve the scientific function of each component of the Center. To be successful, our Research Projects and Cores require innovative designs with measurable, achievable objectives; efficient resource allocation; appropriate implementation; regular, meaningful evaluations; and appropriate statistical analyses. Accordingly, the Research Methods Core’s goals are to make the most efficient use of study resources by standardizing methods for measurement and analysis to the extent possible; to optimize internal and external study validity; and to ensure the relevance of inferential analyses for healthcare providers, policymakers, community leaders, and other key stakeholders. The Research Methods Core’s Specific Aims are to: 1) Integrate with each RP team and other Cores to provide state-of-the- art methodological support for sample size and power calculations, study design, sampling, and implementation; and proactively identify opportunities for disseminating best practices between Research Project teams and Cores, as well as for cross-study collaboration; 2) Maximize the scientific validity of the Research Projects by a) ensuring reliability and validity of study measures; b) standardizing methods for measurement, data collection, and database design to the extent possible; and c) ensuring the reproducibility and transparency of Research Project results; and 3) Apply a flexible and comprehensive quantitative and qualitative data analytic strategy that leverages transdisciplinary Research Methods Core faculty expertise to implement the most reproducible analyses for each Research Project’s Specific Aims. The Core will maximize scientific rigor while accommodating the logistical and methodological challenges that arise in real-world research endeavors. It will leverage both the skills of methodologists with years of experience working on multi-project grants, as well as numerous existing partnerships. The collaboration between the Research Methods Core, Research Projects, and Cores will play a critical role in ensuring that our work contributes to understanding and ameliorating Alzheimer’s disease and related dementias disparities in American Indians, Alaska Natives, and Native Hawaiians, and Pacific Islanders.

研究方法核心：摘要 健康人民2020呼吁研究和政策，以消除种族和民族在健康状况，健康， 行为，功能限制和医疗保健使用。虽然在实现这些目标方面取得了进展， 美洲印第安人、阿拉斯加原住民、夏威夷原住民和太平洋岛民之间的差距仍然很大。这些 老年痴呆症和相关痴呆症的危险因素患病率较高， 这些疾病的诊断不足的风险高于其他群体。因此，原住民在阿尔茨海默氏症 研究中心将在内开展以社区为基础的阿尔茨海默病和相关痴呆症研究 美国印第安人、阿拉斯加原住民、夏威夷原住民和太平洋岛民使用方法和 能够产生准确可靠数据的仪器。研究方法核心的主要功能是协作 与个别研究项目和核心，分享专业知识，以提高每个科学功能 中心的组成部分。为了取得成功，我们的研究项目和核心需要创新的设计， 可衡量的、可实现的目标;有效的资源分配;适当的执行;经常的、 有意义的评价;适当的统计分析。因此，研究方法核心的目标 通过标准化测量和分析方法，最有效地利用研究资源 尽可能;优化内部和外部研究的有效性;并确保推理的相关性 为医疗保健提供者、政策制定者、社区领袖和其他关键利益相关者提供分析。研究 方法核心的具体目标是：1）与每个RP团队和其他核心整合，以提供国家的- 为样本量和把握度计算、研究设计、采样和实施提供方法学支持; 积极主动地寻找在研究项目团队之间传播最佳实践的机会， 核心，以及交叉研究合作; 2）通过a）最大限度地提高研究项目的科学有效性 确保研究测量的可靠性和有效性; B）标准化测量方法，数据收集， 尽可能地进行数据库设计;以及c）确保研究的可重复性和透明度 项目成果;以及3）采用灵活全面的定量和定性数据分析战略， 利用跨学科的研究方法核心教师的专业知识，以实现最可重复的 分析每个研究项目的具体目标。核心将最大限度地提高科学的严谨性， 在现实世界的研究工作中出现的后勤和方法的挑战。它将利用 具有多年多项目赠款工作经验的方法学家的技能，以及许多现有的 伙伴关系。研究方法核心、研究项目和核心之间的合作将发挥 在确保我们的工作有助于理解和改善阿尔茨海默病方面发挥关键作用， 在美洲印第安人、阿拉斯加原住民、夏威夷原住民和太平洋岛民中的相关痴呆差异。