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Increasing Colorectal Cancer Screening in Alaska Native Men

增加阿拉斯加原住民男性结直肠癌筛查

基本信息

批准号：
10218913
负责人：
Clemma Jacobsen Muller
金额：
$ 16.93万
依托单位：
WASHINGTON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-18 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10218913
关键词：
Address Adult Age Alaska Alaska Native American Cancer Society American Indians Blood Cancer Survivor Cessation of life Clinic Clinical Clinical Practice Guideline Colonoscopy Colorectal Cancer Computerized Medical Record Consent DNA Data Diagnosis Diagnostic Disease Economics Enrollment Ensure Ethnic Origin Ethnic group Evidence based intervention Exploratory/Developmental Grant Feces Feedback Focus Groups Foundations Frequencies Future Guidelines Health Health Care Visit Health Personnel Healthcare Systems Home Incidence Individual Intervention Intervention Trial Interview Lesion Life Malignant Neoplasms Methods Minority Groups Morbidity - disease rate Native-Born Not Hispanic or Latino Patient Recruitments Patients Population Preparation Procedures Race Randomized Randomized Controlled Trials Reaction Reporting Research Risk Schedule Screening Result Structure Surveys Survival Rate Survivors Testing Text Messaging TimeLine Treatment outcome Underserved Population Woman Workload aged base cancer diagnosis cancer health disparity clinical practice colorectal cancer prevention colorectal cancer risk colorectal cancer screening colorectal cancer treatment comparison intervention cost design economic evaluation effective intervention effectiveness testing electronic data ethnic minority population experience follow-up health economics high risk high risk population home test implementation study improved informant male man men mortality patient response post intervention preference premalignant prevent primary outcome racial minority screening screening disparities screening guidelines secondary outcome text messaging intervention theories therapy design treatment arm treatment as usual uptake waiver

项目摘要

ABSTRACT Alaska Native men have higher colorectal cancer (CRC) incidence and mortality than any other US racial or ethnic group. Screening can prevent CRC and improve treatment outcomes by detecting disease in early stages, but Alaska Native men also have low CRC screening uptake. Colonoscopy is the most accurate CRC screening method and results in the most years of life saved. It only requires rescreening every 10 years, but it is a clinic- based procedure and needs extensive preparation. Other screening options include home-based tests that detect blood in the stool and require rescreening every year. More recently, a home-based method has been developed that tests stool for DNA indicative of CRC and requires rescreening every 3 years. Current guidelines recommend CRC screening for average risk adults starting between ages 45-50, but people at higher risk should start at younger ages. Many interventions have been developed to promote CRC screening. Among these, interventions that use text messaging or other electronic health messages to reach people outside of the clinical setting have shown promise for improving CRC screening. In a previous study, our research team developed an intervention that sends up to 3 text messages to Alaska Native people patients of the Southcentral Foundation (SCF) healthcare system in Anchorage, Alaska. We tested the intervention in a randomized controlled trial with 2,386 Alaska Native SCF patients ages 40-75. The intervention increased CRC screening by 50% in women, but it had no effect in men. In the current implementation study, we propose a theory-based approach to culturally tailor the existing text message intervention for Alaska Native men. We will use surveys and focus groups with SCF patients, and key informant interviews with SCF healthcare providers, to assess barriers and facilitators to optimize colorectal cancer screening in Alaska Native men. We anticipate that revisions will include changing the content and frequency of the text messages, and promoting home-based stool DNA screening in addition to colonoscopy. We will then test the effectiveness of the tailored intervention with 600 Alaska Native men ages 40-75 who are active patients at SCF. Eligible men will be identified from the electronic medical record and randomized in equal proportions to the intervention or usual care control conditions. The primary outcome is CRC screening completed within 6 months of sending the first text message. Secondary outcomes include clinical findings and follow-up procedures associated with screening. All data will be collected from the electronic medical record, and we will obtain a waiver of consent for direct patient recruitment. Follow-up interviews will assess patient response to the intervention. If effective, this study has implications for increasing CRC screening in men from other racial and ethnic minority groups who experience CRC disparities.

摘要