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Flexible bioelectronic sensors for non-contact detection of obstruction in pediatric vascular shunts

用于非接触式检测儿科血管分流阻塞的柔性生物电子传感器

基本信息

批准号：
10171845
负责人：
Ellis Meng
金额：
$ 29.88万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10171845
关键词：
Acute Address Animals Arteries Blood Blood Substitutes Blood Vessels Blood flow Caliber Cardiovascular system Catheters Child Childhood Chronic Clinical Clinical Trials Common Ventricle Computer software Coupled Coupling Critical Care Data Defect Detection Deterioration Development Drainage procedure Early Diagnosis Electric Capacitance Electrodes Electronics Emergency Situation Encapsulated Ensure Failure Functional disorder Future Goals Heart Heart Abnormalities Heart Ventricle Hypoxia Implant Industrialization Infant Intervention Lead Life Liquid substance Literature Location Lung Measurement Measures Methods Modeling Modification Monitor Morbidity - disease rate Newborn Infant Obstruction Operative Surgical Procedures Outcome Patients Pediatric cardiology Performance Perfusion Periodicity Physiology Preparation Procedures Pulmonary Circulation Pulmonary artery structure Pulsatile Flow Reporting Research Resistance Resolution Resuscitation Risk Saline Shunt Device Source Staging Sudden Death Surgical sutures System Technology Telemetry Thrombus Time Vascular Graft Width Wireless Technology Work base care costs data acquisition design flexibility hazard high reward high risk imaging modality in vivo in vivo evaluation instrumentation invention mortality neonatal patient neonate palliation palliative patient home care porcine model pre-clinical preservation prevent prototype reconstruction response sensor side effect standard of care thrombotic complications

项目摘要

Neonatal patients having one or two ventricle defects are dependent on the modified Blalock-Taussig shunt (mBTS) to establish proper systemic blood flow. While the procedure has saved many newborns with cyanotic heart defects, the obstruction of mBTS due to either thrombus and/or intimal build up has been problematic leading to high mortality and morbidity. In addition, the cost of care is among the most expensive for any surgical procedure. Shunt obstruction can lead to hypoxia and sudden death due to insufficient pulmonary circulation. Shunt occlusion can be sudden and without enough warning to prevent rapid deterioration of the patient’s condition. Alternatively, shunt obstruction can also occur gradually. But even in this case, the narrowing of the shunt lumen may result in similar adverse side effects. When emergency intervention is required, despite very aggressive resuscitation, it is frequently difficult to save infants with shunt obstruction. Recanalization can correct shunt obstruction. Imaging methods are inadequate to resolve obstruction within these 3-5 mm diameter shunts. Therefore, early detection of shunt obstruction is critical to avoid the need for emergency intervention and preventable loss of life. This proposal addresses the unmet clinical need for miniature sensors that can detect significant changes in blood flow through mBTS necessitating intervention. Developing flow sensors suitable for use with shunts poses several unique challenges but if successful, can reduce morbidity and mortality through timely, informed recanalization. The systematic approach involves first demonstrating proof-of-concept at the benchtop of non-contact flow sensing, followed by developing shunt sensor systems suitable for in vivo use, and then a final demonstration of wired sensors in a pig model. The expected outcome of this work is the demonstration of a non-contact flow sensor suitable for use with shunts to enable a sensor-shunt system as mBTS. The successful demonstration will pave the way for development of a wireless telemetry to enable a wireless mBTS for chronic animal studies. The non-contact sensing method also can be applied to other synthetic vascular grafts or drainage shunts. This proposal will establish proof-of-concept that is critical to achieve the long term goal of a wirelessly interrogated flow sensor system for periodic monitoring in a home care setting that enables early warning to drive intervention that saves lives.

有一个或两个心室缺陷的新生儿患者依赖于改良的Blalock-Taussig