HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)

HORNET 自主神经记录和刺激系统中心 (CARSS)

• 批准号: 10557005
• 负责人: Ellis Meng
• 金额: $ 48.77万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557005
• 关键词: 3-Dimensional; Address; Adopted; Ally; Architecture; Autonomic nervous system disorders; Biocontrols; Caliber; Clinical; Complement; Custom; Electrodes; Equilibrium; Film; Foreign Bodies; Health; Hypertension; Immune response; Implant; Individual; Inflammatory Bowel Diseases; Lead; Measures; Medical; Medicine; Memory; Metals; Methods; Microfabrication; Molds; Nerve; Nerve Fibers; Non-Insulin-Dependent Diabetes Mellitus; Operative Surgical Procedures; Perineuriums; Peripheral; Peripheral Nerves; Peripheral Nervous System; Polymers; Process; Recording of previous events; Research; Rheumatoid Arthritis; Rotation; Scheme; Shapes; Site; Source; Structure; Surgical sutures; System; Technology; Testing; Thick; Thinness; Welding; autonomic nerve; base; bioelectronics; cost; design; flexibility; instrument; interest; miniaturize; minimally invasive; novel; open source; parylene; parylene C; polydimethylsiloxane; preservation; tool; wound

Implanted leads are critical for direct interfaces to the peripheral nervous system and have been used clinically since the 1960s. Even so, no open-architecture or open-source leads are available for autonomic nerve stimulation and recording. This is especially a problem for interfacing with soft, small diameter nerves measuring 1 mm or less. Since these are of great interest as targets in bioelectronic medicine, NEST 4 will introduce a new open-architecture nerve interface based on a helical cuff format. This cuff addresses the limitations of downscaling traditional materials and fabrication methods for polydimethylsiloxane-based cuffs and instead adopts a different scheme to achieve practical nerve cuffs using a composite Parylene C-PDMS structure. The CARSS helical microfabricated cuff uses soft polymers and thin film electrodes to achieve a miniaturized cuff form factor. The contra-rotational helical cuff design is achieved by post-processing the Parylene electrode array using a thermoforming process to achieve the final three-dimensional shape. The helical design is self- sizing and self-closing which avoids the need for sutures. The cuff is accompanied by a minimally invasive, custom endoscopic tool that will simplify surgery and allow access to deeper autonomic nerve branches. In NEST 4, the Parylene helical cuff will be developed, benchtop tested, and demonstrated with the surgical placement tool, paving the way for a widely accessible cuff for smaller nerves in clinical bioelectronic medicine research.

植入式电极导线对于外周神经系统的直接接口至关重要，并已在临床上使用 从1960年代开始。即便如此，自主神经的开放架构或开放源代码的导线仍然不可用 刺激和记录。这对于与软的、小直径的神经连接尤其是一个问题， 1 mm或更小。由于这些作为生物电子医学中的目标引起了人们的极大兴趣，NEST 4将引入一种新的 开放式结构的神经接口的基础上的螺旋袖口格式。该袖带解决了 缩小用于聚二甲基硅氧烷基袖带的传统材料和制造方法， 采用不同的方案来实现使用复合Parylene C-PDMS结构的实用神经袖带。 CARSS螺旋微加工袖带使用软聚合物和薄膜电极来实现微型化。 袖带形状因数。通过对聚对二甲苯电极进行后处理，实现对旋螺旋袖带设计 阵列使用热成型工艺来实现最终的三维形状。螺旋设计是自- 尺寸和自闭合，从而避免了缝合的需要。袖带是伴随着一个微创， 定制的内窥镜工具，将简化手术，并允许进入更深的自主神经分支。 在NEST 4中，将开发聚对二甲苯螺旋套囊，进行台架测试，并使用外科手术进行演示。 放置工具，为临床生物电子医学中较小神经的广泛使用袖带铺平了道路 research.