Flexible neural probe arrays for large-scale cortical and subcortical recording

用于大规模皮层和皮层下记录的灵活神经探针阵列

• 批准号: 9231808
• 负责人: Ellis Meng
• 金额: $ 41.61万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9231808
• 关键词: Action Potentials; Address; Affect; Animals; Area; Biological; Biomedical Engineering; Brain; Caliber; Chronic; Complement; Coupled; Custom; Development; Devices; Electrodes; Electronics; Electrophysiology (science); Encapsulated; Engineering; Evaluation; Failure; Future; Gel; Goals; Gold; Hippocampus (Brain); Human; Immune response; Implant; Length; Mechanics; Medical; Metals; Methods; Microfabrication; Modeling; Monitor; Neurons; Noise; Operative Surgical Procedures; Outcome; Outcomes Research; Performance; Polyethylene Glycols; Polymers; Process; Property; Prosthesis; Protocols documentation; Rattus; Sepharose; Side; Signal Transduction; Silicon; Site; Solid; Structure; Surface; System; Techniques; Technology; Telemetry; Testing; Time; Tissues; Width; Wireless Technology; Work; analog; base; biodegradable polymer; brain machine interface; cranium; density; design; digital; flexibility; implantation; improved; in vivo; innovation; nervous system disorder; neural prosthesis; neuroprosthesis; next generation; novel; parylene; relating to nervous system; technological innovation; theories

Implantable neural electrodes have enjoyed decades of development but the ability to record resolvable neuronal activities is often reduced or completely lost over time. This is true regardless of species with recording lifetimes of months to at best a few years in animal; although select neural probes have been successfully implemented in human, the recording lifetimes are short (<5 years). Overcoming the limitations of today’s implant technologies could revolutionize the design of future neural prosthetic platforms, which in turn, would have a profound impact on the medical treatment of multiple neurological disorders using brain-machine interfaces. The goal of this proposal is to achieve large scale recordings over long periods of time. To achieve a stable, long-term neuronal interface, we will use a multi-pronged approach involving innovation in polymer micromachining and integration and packaging and the application of principles of solid mechanics and beam theory. Multi-level polymer micromachining will enable high electrode density on both sides of single shanks with minimal area dedicated to wiring. Multiple shanks will be connected by a backplane consisting of a ribbon cable into which electrical connectivity has been established with an embedded application specific integrated circuit (ASIC) chip. The chip contains circuits that provide signal amplification and multiplexing; the latter will greatly reduce the number of external wire connections and thus the footprint required for the overall implant. By leveraging the increase in stiffness of a shank as length decreases and biodegradable polymers, deep implantation of bare probes and probe arrays will be realized without the use of existing stiffener approaches that increase the cross sectional diameter by orders of magnitude. The collaborative team consists of biomedical engineer with specific expertise in microfabrication of implantable systems, a circuit expert, and a biomedical engineer with expertise in neural engineering of hippocampal prostheses. Together, we will develop the probe array technology and achieve integration of microelectronic circuits. In addition, the new probe array system will be demonstrated in rat to collect electrophysiological recordings in the hippocampus and compared to the performance of gold standard microwire array implants. These studies will be complemented by histological analysis.

植入式神经电极已经经历了几十年的发展，但记录的能力 随着时间的推移，可分辨的神经元活动通常会减少或完全丧失。这是事实，无论 记录动物寿命为数月至最多数年的物种；尽管选择神经探针 已在人类中成功实施，记录寿命很短（<5年）。克服 当今植入技术的局限性可能会彻底改变未来神经假体的设计 平台，反过来将对多种神经系统疾病的医疗产生深远影响 使用脑机接口的疾病。 该提案的目标是实现长时间的大规模记录。为了达到一个 为了稳定、长期的神经元接口，我们将采用多管齐下的方法，涉及聚合物的创新 微机械加工、集成和封装以及固体力学原理的应用和 梁理论。多级聚合物微加工将在单面两侧实现高电极密度 具有最小面积的专用于接线的柄。多个刀柄将通过一个背板连接，该背板包括 带状电缆的电气连接已通过嵌入式应用程序建立 专用集成电路（ASIC）芯片。该芯片包含提供信号放大和 多路复用；后者将大大减少外部接线的数量，从而减少占地面积 整个种植体所需的。随着长度的减小，利用柄的刚度增加 和可生物降解聚合物，将实现裸探针和探针阵列的深部植入，无需 使用现有的加强筋方法将横截面直径增加几个数量级。 该协作团队由在微制造方面具有特定专业知识的生物医学工程师组成 植入系统、电路专家和具有神经工程专业知识的生物医学工程师 海马假体。我们将共同开发探针阵列技术并实现集成 微电子电路。此外，新的探针阵列系统将在大鼠中进行演示以收集 海马体电生理记录并与金标准的表现进行比较 微丝阵列植入物。这些研究将得到组织学分析的补充。